| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Minichromosome maintenance protein MCM |
Protein Synonyms/Alias | |
Gene Name | MCM |
Gene Synonyms/Alias | SSO0774 |
Created Date | 3-June-2014 |
Organism | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) |
NCBI Taxa ID | 273057 |
Phosphorylation | Position | Peptide | Code | Type | References | | 516 | DIDTLRKYIAYARKY | Y | HTP | [1] | | 141 | KERIYKATYKHIHPD | T | HTP | [1] | | 519 | TLRKYIAYARKYVTP | Y | HTP | [1] | | 138 | TPVKERIYKATYKHI | Y | HTP | [1] | | 142 | ERIYKATYKHIHPDC | Y | HTP | [1] | |
Reference | [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus. Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [ PMID:22639831] |
Functional Description From UniProt | FUNCTION: Presumptive replicative helicase. Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single- stranded DNA binding protein). The active ATPase sites in the MCM ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP- binding site of the Walker A box of the adjacent subunit. The helicase function is proposed to use a partially sequential mode of ATP hydrolysis; the complex appears to tolerate multiple catalytically inactive subunits |
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| 3D-structure; ATP-binding; Completeproteome; DNAreplication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Referenceproteome |
Protein Sequence | MEIPSKQIDY RDVFIEFLTT FKGNNNQNKY IERINELVAY RKKSLIIEFS DVLSFNENLA 60
YEIINNTKII LPILEGALYD HILQLDPTYQ RDIEKVHVRI VGIPRVIELR KIRSTDIGKL 120
ITIDGILVKV TPVKERIYKA TYKHIHPDCM QEFEWPEDEE MPEVLEMPTI CPKCGKPGQF 180
RLIPEKTKLI DWQKAVIQER PEEVPSGQLP RQLEIILEDD LVDSARPGDR VKVTGILDIK 240
QDSPVKRGSR AVFDIYMKVS SIEVSQKVLD EVIISEEDEK KIKDLAKDPW IRDRIISSIA 300
PSIYGHWELK EALALALFGG VPKVLEDTRI RGDIHILIIG DPGTAKSQML QFISRVAPRA 360
VYTTGKGSTA AGLTAAVVRE KGTGEYYLEA GALVLADGGI AVIDEIDKMR DEDRVAIHEA 420
MEQQTVSIAK AGIVAKLNAR AAVIAAGNPK FGRYISERPV SDNINLPPTI LSRFDLIFIL 480
KDQPGEQDRE LANYILDVHS GKSTKNIIDI DTLRKYIAYA RKYVTPKITS EAKNLITDFF 540
VEMRKKSSET PDSPILITPR QLEALIRISE AYAKMALKAE VTREDAERAI NIMRLFLESV 600
GVDMESGKID IDTIMTGKPK SAREKMMKII EIIDSLAVSS ECAKVKDILK EAQQVGIEKS 660
NIEKLLTDMR KSGIIYEAKP ECYKKV 686 |
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