※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase
Protein Synonyms/Alias
 SHMT;  Serine methylase
Gene Name
 glyA
Gene Synonyms/Alias
 SSO0530; ORFNames=C22_021
Created Date
 3-June-2014
Organism
 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
NCBI Taxa ID
 273057
Phosphorylation
Position
Peptide
Code
Type
References
414 NFLEVKYTFDDMKDL T HTP [1]
413 RNFLEVKYTFDDMKD Y HTP [1]
Reference
 [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus.
 Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC
 J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [PMID:22639831]
Functional Description From UniProt
 FUNCTION: Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one- carbon carrier. Can not use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta- phenylserine
Sequence Annotation From UniProt
 MOD_RES 227 227 N6-(pyridoxal phosphate)lysine (By
Key Word From UniProt
 Amino-acidbiosynthesis; Completeproteome; Cytoplasm; Directproteinsequencing; One-carbonmetabolism; Pyridoxalphosphate; Referenceproteome; Transferase
Protein Sequence
 MSLPKELEKV LEITKAQNVW RRTQTLNLIA SENVMSPLAE SVYMSDFMSR YAEGKPYKRY 60
 YQGTKYTDEI ETLTMELMNE ITNSKDCDLR PTSGTIANAA VFRVLAEPGD KALIAPVQAG 120
 AHVSHTKFGT LGALGIQHIE MPFDEENINV DVDKAIKMIE EVKPKFVVLG GSLYLFPHPT 180
 KELAQHVHAV GAKLVYDAAH VYGLIEGKVW SNPLKDGADI MTVSTHKTFP GPQGGAIFSD 240
 GSEVFKQVSK TIFPWFVSNH HLHRLPATAV TAIEMKYFGE SYANQILRNS KALAEALAER 300
 GFKVIGENLG YTKSHQVAVD VRQFGGGNKI AKLLEDANII VNKNLLPYDK PEDVSDPSGL 360
 RIGVQEMTRY GMKEGEMEEI AELFKKVIID KKDVNEVKKE VIEMRRNFLE VKYTFDDMKD 420
 LEKYSSKSLK LII 433
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004372   F:glycine hydroxymethyltransferase activity IEA:UniProtKB-HAMAP
  GO:0030170   F:pyridoxal phosphate binding IEA:UniProtKB-HAMAP
  GO:0019264   P:glycine biosynthetic process from serine IEA:UniProtKB-HAMAP
  GO:0006730   P:one-carbon metabolic process IEA:UniProtKB-HAMAP
  IPR015424   PyrdxlP-dep_Trfase.
  IPR015421   PyrdxlP-dep_Trfase_major_sub1.
  IPR015422   PyrdxlP-dep_Trfase_major_sub2.
  IPR001085   Ser_HO-MeTrfase.
  IPR019798   Ser_HO-MeTrfase_PLP_BS.
  PF00464   SHMT.
  PS00096   SHMT.