Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine hydroxymethyltransferase |
Protein Synonyms/Alias | SHMT; Serine methylase |
Gene Name | glyA |
Gene Synonyms/Alias | SSO0530; ORFNames=C22_021 |
Created Date | 3-June-2014 |
Organism | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) |
NCBI Taxa ID | 273057 |
Phosphorylation | Position | Peptide | Code | Type | References | 414 | NFLEVKYTFDDMKDL | T | HTP | [1] | 413 | RNFLEVKYTFDDMKD | Y | HTP | [1] | |
Reference | [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus. Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [ PMID:22639831] |
Functional Description From UniProt | FUNCTION: Catalyzes the reversible interconversion of serine and glycine with the modified folate sulfopterin serving as the one- carbon carrier. Can not use tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of both allo-threonine and beta- phenylserine |
| MOD_RES 227 227 N6-(pyridoxal phosphate)lysine (By |
| Amino-acidbiosynthesis; Completeproteome; Cytoplasm; Directproteinsequencing; One-carbonmetabolism; Pyridoxalphosphate; Referenceproteome; Transferase |
Protein Sequence | MSLPKELEKV LEITKAQNVW RRTQTLNLIA SENVMSPLAE SVYMSDFMSR YAEGKPYKRY 60 YQGTKYTDEI ETLTMELMNE ITNSKDCDLR PTSGTIANAA VFRVLAEPGD KALIAPVQAG 120 AHVSHTKFGT LGALGIQHIE MPFDEENINV DVDKAIKMIE EVKPKFVVLG GSLYLFPHPT 180 KELAQHVHAV GAKLVYDAAH VYGLIEGKVW SNPLKDGADI MTVSTHKTFP GPQGGAIFSD 240 GSEVFKQVSK TIFPWFVSNH HLHRLPATAV TAIEMKYFGE SYANQILRNS KALAEALAER 300 GFKVIGENLG YTKSHQVAVD VRQFGGGNKI AKLLEDANII VNKNLLPYDK PEDVSDPSGL 360 RIGVQEMTRY GMKEGEMEEI AELFKKVIID KKDVNEVKKE VIEMRRNFLE VKYTFDDMKD 420 LEKYSSKSLK LII 433 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0004372 F:glycine hydroxymethyltransferase activity IEA:UniProtKB-HAMAP GO:0030170 F:pyridoxal phosphate binding IEA:UniProtKB-HAMAP GO:0019264 P:glycine biosynthetic process from serine IEA:UniProtKB-HAMAP GO:0006730 P:one-carbon metabolic process IEA:UniProtKB-HAMAP |
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