UniProt Accession

 FLPA_SULAC;  Q9P9M0;  Q4J954

Genbank Protein ID

 AF201093;  CP000077

Genbank Nucleotide ID

 AAF69254.1;  AAY80681.1

Protein Name

 Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase

Protein Synonyms/Alias

 

Gene Name

 flpA

Gene Synonyms/Alias

 fib; OrderedLocusNames=Saci_1346

Created Date

 3-June-2014

Organism

 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)

NCBI Taxa ID

 330779

Phosphorylation

Reference

 [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius.
 Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV
 Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [PMID:24078887]

Functional Description From UniProt

 FUNCTION: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; Methyltransferase; RNA-binding; rRNAprocessing; Transferase; tRNAprocessing

Protein Sequence

  GO:0008168   F:methyltransferase activity IEA:UniProtKB-HAMAP
  GO:0003723   F:RNA binding IEA:UniProtKB-HAMAP
  GO:0006364   P:rRNA processing IEA:UniProtKB-HAMAP
  GO:0008033   P:tRNA processing IEA:UniProtKB-HAMAP

  IPR000692   Fibrillarin.
  IPR020813   Fibrillarin_CS.

  PF01269   Fibrillarin.

  PS00566   FIBRILLARIN.

  PR00052   FIBRILLARIN.