※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphomethylpyrimidine synthase
Protein Synonyms/Alias
 HMP-P synthase;  HMP-phosphate synthase;  HMPP synthase
Gene Name
 thiC
Gene Synonyms/Alias
 PA4973
Created Date
 3-June-2014
Organism
 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
NCBI Taxa ID
 208964
Phosphorylation
Position
Peptide
Code
Type
References
155 IITPEMEYIAIRENM Y HTP [1]
Reference
 [1]Ser/Thr/Tyr phosphoproteome analysis of pathogenic and non-pathogenic Pseudomonas species.
 Ravichandran A,Sugiyama N,Tomita M,Swarup S,Ishihama Y
 Proteomics 2009, May;9(10):2764-75. [PMID:19405024]
Functional Description From UniProt
 FUNCTION: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 4Fe-4S; Completeproteome; Iron; Iron-sulfur; Lyase; Metal-binding; Referenceproteome; S-adenosyl-L-methionine; Thiaminebiosynthesis; Zinc
Protein Sequence
 MSATQKNNIT RLEQLDRQST QPFPNSRKVY LTGSRPDIRV PVREISLADT PTAFGGEKNP 60
 PVFVYDTSGP YTDPEVRIDL RKGLPDVRSR WIDERGDTEI LPGLTSEFGQ ARLADASLDA 120
 LRFAHVRTPR RAKPGANVSQ MHYAKKGIIT PEMEYIAIRE NMKLQEARAA GLLDQQHPGH 180
 SFGANIPKEI TPEFVREEVA RGRAIIPANI NHTELEPMII GRNFLVKING NIGNSALGSS 240
 IEEEVEKLTW GIRWGADTVM DLSTGKHIHE TREWILRNSP VPIGTVPIYQ ALEKVNGVAE 300
 DLTWEIFRDT LIEQAEQGVD YFTIHAGVLL RYVPLTAKRV TGIVSRGGSI MAKWCLAHHQ 360
 ENFLYTHFEE ICEIMKAYDV SFSLGDGLRP GSVADANDAA QFGELETLGE LTKIAWKHDV 420
 QVMIEGPGHV PMQLIKENMD KQLECCDEAP FYTLGPLTTD IAPGYDHITS GIGAAMIGWF 480
 GCAMLCYVTP KEHLGLPNKD DVKTGIITYK IAAHAADLAK GHPGAQIRDN ALSKARFEFR 540
 WEDQFNLGLD PDTARAFHDE TLPKDSAKVA HFCSMCGPKF CSMKITQEVR DYAKENGLSD 600
 ESKAIEAGFQ EQAARFKDEG SVIYRQV 627
  GO:0051539   F:4 iron, 4 sulfur cluster binding IEA:UniProtKB-KW
  GO:0016829   F:lyase activity IEA:UniProtKB-HAMAP
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0009228   P:thiamine biosynthetic process IEA:UniProtKB-HAMAP
  GO:0009229   P:thiamine diphosphate biosynthetic process IEA:UniProtKB-UniPathway
  IPR002817   ThiC.
  IPR025747   ThiC-associated_dom.
  PF01964   ThiC.
  PF13667   ThiC-associated.