| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase |
Protein Synonyms/Alias | |
Gene Name | ispH |
Gene Synonyms/Alias | lytB; OrderedLocusNames=SCO5058 |
Created Date | 3-June-2014 |
Organism | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
NCBI Taxa ID | 100226 |
Phosphorylation | Position | Peptide | Code | Type | References | | 306 | IVKAAEESIIFSLPK | S | HTP | [1] | |
Reference | [1]Phosphoproteome analysis of Streptomyces development reveals extensive protein phosphorylation accompanying bacterial differentiation. Manteca A,Ye J,Sánchez J,Jensen ON J. Proteome Res. 2011, Dec, 2;10(12):5481-92. [ PMID:21999169] |
Functional Description From UniProt | FUNCTION: Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) |
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| 3Fe-4S; Completeproteome; Iron; Iron-sulfur; Isoprenebiosynthesis; Metal-binding; NADP; Oxidoreductase; Referenceproteome |
Protein Sequence | MGAMTASPGR RVLLAAPRGY CAGVDRAVIA VEKALEQYGA PVYVRHEIVH NKYVVQTLEK 60
KGAIFVERTE EVPEGNIVMF SAHGVAPVVH EEAERGKLAT IDATCPLVTK VHKEAVRFAN 120
DDYDILLIGH EGHEEVIGTS GEAPDHIQLV DGPEDVAKVE VRDPSKVVWL SQTTLSVDET 180
METVDALKDK FPQLISPPSD DICYATQNRQ LAVKQMGAEA ELVIVVGSRN SSNSKRLVEV 240
AKQAGSRAAY LVDFADEIDE TWLDGVTTVG VTSGASVPDV LVEQVLEWLS RRGFEDVEIV 300
KAAEESIIFS LPKELRRDLR EEAASLVAER GGSGTAGA 338 |
| GO:0051538 F:3 iron, 4 sulfur cluster binding IEA:UniProtKB-HAMAP GO:0051745 F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity IEA:UniProtKB-HAMAP GO:0046872 F:metal ion binding IEA:UniProtKB-KW GO:0050992 P:dimethylallyl diphosphate biosynthetic process IEA:UniProtKB-UniPathway GO:0019288 P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA:UniProtKB-HAMAP GO:0016114 P:terpenoid biosynthetic process IEA:UniProtKB-HAMAP |
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