※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phosphocarrier protein HPr
Protein Synonyms/Alias
 
Gene Name
 ptsH
Gene Synonyms/Alias
 
Created Date
 3-June-2014
Organism
 Bacillus thuringiensis subsp. israelensis
NCBI Taxa ID
 1430
Phosphorylation
Position
Peptide
Code
Type
References
45 GKNVNLKSIMGVMSL S LTP [1],UniProt
Reference
 [1]Loss of catabolite repression function of HPr, the phosphocarrier protein of the bacterial phosphotransferase system, affects expression of the cry4A toxin gene in Bacillus thuringiensis subsp. israelensis.
 Khan SR,Banerjee-Bhatnagar N
 J. Bacteriol. 2002, Oct;184(19):5410-7. [PMID:12218029]
Functional Description From UniProt
 FUNCTION: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the permease (enzymes II/III)
Sequence Annotation From UniProt
 MOD_RES 14 14 Tele-phosphohistidine; alternate
 MOD_RES 45 45 Phosphoserine; by HPrK/P
Key Word From UniProt
 Cytoplasm; Directproteinsequencing; Kinase; Phosphoprotein; Phosphotransferasesystem; Serine/threonine-proteinkinase; Sugartransport; Transcription; Transcriptionregulation; Transferase; Transport
Protein Sequence
 MEKIFKVTSD SGIHARPATL LVNTASKFGS DINLEYNGKN VNLKSIMGVM SLGIQQNAEI 60
 KITANGDDAA QALAAIEETM KNEGLGE 87
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  GO:0005351   F:sugar:hydrogen symporter activity IEA:InterPro
  GO:0009401   P:phosphoenolpyruvate-dependent sugar phosphotransferase system IEA:UniProtKB-KW
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR000032   HPr_prot-like.
  IPR001020   PTS_HPr_His_P_site.
  IPR002114   PTS_HPr_Ser_P_site.
  PF00381   PTS-HPr.
  PS51350   PTS_HPR_DOM.
  PS00369   PTS_HPR_HIS.
  PS00589   PTS_HPR_SER.
  PR00107   PHOSPHOCPHPR.