| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mycothiol S-conjugate amidase |
Protein Synonyms/Alias | |
Gene Name | mca |
Gene Synonyms/Alias | SCO4967 |
Created Date | 3-June-2014 |
Organism | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
NCBI Taxa ID | 100226 |
Phosphorylation | Position | Peptide | Code | Type | References | | 279 | AKSLVETSLPEDDLF | S | HTP | [1] | |
Reference | [1]Phosphoproteome analysis of Streptomyces development reveals extensive protein phosphorylation accompanying bacterial differentiation. Manteca A,Ye J,Sánchez J,Jensen ON J. Proteome Res. 2011, Dec, 2;10(12):5481-92. [ PMID:21999169] |
Functional Description From UniProt | FUNCTION: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics |
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| Completeproteome; Hydrolase; Metal-binding; Referenceproteome; Zinc. |
Protein Sequence | MTDQLRLMAV HAHPDDESSK GAATMAKYVS EGVDVLVVTC TGGERGSILN PKLQGDAYIE 60
ENIHEVRRKE MDEAREILGV GQEWLGFVDS GLPEGDPLPP LPEGCFALED VDKAAGELVR 120
KIRSFRPQVI TTYDENGGYP HPDHIMTHKI TMVAFEGAAD TEKYPESEYG TAYQPLKVYY 180
NQGFNRPRTE ALHHALLDRG LESPYEDWLK RWSEFERKER TLTTHVPCAD FFEIRDKALI 240
AHATQIDPEG GWFRVPMEIQ KEVWPTEEYE LAKSLVETSL PEDDLFAGIR DNA 293 |
| GO:0016787 F:hydrolase activity IEA:UniProtKB-KW GO:0008270 F:zinc ion binding IEA:UniProtKB-HAMAP GO:0010126 P:mycothiol metabolic process IMP:UniProtKB GO:0010127 P:mycothiol-dependent detoxification IMP:UniProtKB |
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