| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Reverse gyrase 1 |
Protein Synonyms/Alias | |
Gene Name | rgy1 |
Gene Synonyms/Alias | SSO0420 |
Created Date | 3-June-2014 |
Organism | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) |
NCBI Taxa ID | 273057 |
Phosphorylation | Position | Peptide | Code | Type | References | | 702 | KFIPIYSTIKKCEKG | T | HTP | [1] | | 700 | DSKFIPIYSTIKKCE | Y | HTP | [1] | | 701 | SKFIPIYSTIKKCEK | S | HTP | [1] | |
Reference | [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus. Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [ PMID:22639831] |
Functional Description From UniProt | FUNCTION: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity). Its activity is inhibited by the DNA-binding protein 7d (Sso7d), suggesting that the Sso7d activity might counteract the overwinding effect of reverse gyrase |
| |
| ATP-binding; Completeproteome; DNA-binding; Helicase; Hydrolase; Isomerase; Magnesium; Metal-binding; Nucleotide-binding; Referenceproteome; Topoisomerase; Zinc; Zinc-finger |
Protein Sequence | MTSINKVPPS IYTRSCPNCG GNISSQRLFN GSVCESCLKD DREFSNLSDL INILSENSNL 60
KNLTQIRDVL EEYKKVEEIF GKLLNNSKPI GPQRSWTIRF LRGESFAIIA PPGLGKTTFG 120
LIMSLYNATR NRKSIIIFPT RTLISQTVDK LAKFSELYSY SPRILYNKQS PTQTENILDQ 180
LKSGNFDIFI STNRFVIQNL SELSNIKFDF IFVDDVDAAL KSGKSAKAIL RLVGFTDEDI 240
QTTMKLLREN IGEEEKFGKI QEIRESRLKD KIVIFSSATI SRGNPILSSL MGFRPGSSVI 300
YLRNIYDSYI DLTQTCKGQD FEECTLGTVI KLLKRLNDGT LIFVPIDKGA QYADYLASNL 360
RDHGINVESV ASSSISKLEK FERGEVSSLV GVATHYGVLV RGIDLPWRVK YSIFVGIPKF 420
KFKIGEYMHP LALTRLLSLV YLVKNDDKVR GLLSYIRKRL RKISPAALAM LAKDIREGKI 480
DDERLKEAYN LVNEYLKDNE FLKKVSDVGD LVIEGDYILM PDYLTYIQAS GRTSRLYGAN 540
LTTGLSVLLI DNSRLFELLN KKLNLILDEV KWYSLDIDAD KLGQVSLSDI SAKITEERES 600
LSKIKKEGNV ESSSLSVKTT LFIVESPNKA KTISNFFSRP STRSYGKLRV YETVLGDRVL 660
IVAASGGHIY DLITEDESEK QDDNYVYGVL VKDSKFIPIY STIKKCEKGH QIVKDLSQNK 720
CPICGSRIVT DKTEVVDILR KLALEVDEVL IGTDPDTEGE KIAWDIYLAI RPFNGNIKRA 780
EFHEVTRRAI LNAIKNPREF NDNLVKSQIV RRIEDRWIGF KLSRKLQTEF WEQHCTSISK 840
KNSKDEECKE NRNLSAGRVQ TPVLDWVVNR YQKYNENKKK YLIIESQDKS IFPFSVLALK 900
KNGLSKNTQI IIHLEDINIK EEEFGPLPPY TTDTLLSDAA NLLRIPASDT MRVAQDLFEL 960
GLITYHRTDS TRVSNVGISV AETYLKSKQV DISKIFRPRS WGEGGAHEAI RPTKPLDETM 1020
LKASIEQGDL ELSKQLTFNH FRVYNLIFRR FITSQLPPLV VTKQIVRIRA YTKDNIELEL 1080
DENKKEFVIG YKLKEGDEFR QTLQDAIYTL FRLYQPLDEK MKGKELSATI TGTLNKSDVQ 1140
LYTEGELISE MKSKQIGRPS TYAVIISTLK KRRYIIESKN LKKIIPTKLG MAVKEYLMEN 1200
YKQIVSEKRT VKLLEKMNEV EEGKVDYLVL LKELYNEIQT IS 1242 |
| GO:0005694 C:chromosome IEA:InterPro GO:0005524 F:ATP binding IEA:UniProtKB-HAMAP GO:0008026 F:ATP-dependent helicase activity IEA:InterPro GO:0003677 F:DNA binding IEA:UniProtKB-HAMAP GO:0003917 F:DNA topoisomerase type I activity IEA:InterPro GO:0003918 F:DNA topoisomerase type II (ATP-hydrolyzing) activity IEA:UniProtKB-HAMAP GO:0000287 F:magnesium ion binding IEA:UniProtKB-HAMAP GO:0008270 F:zinc ion binding IEA:UniProtKB-HAMAP GO:0006265 P:DNA topological change IEA:UniProtKB-HAMAP GO:0006268 P:DNA unwinding involved in DNA replication IEA:UniProtKB-HAMAP |
| |
| |
| |
| |
| |
