※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable 2-isopropylmalate synthase
Protein Synonyms/Alias
 
Gene Name
 leuA
Gene Synonyms/Alias
 SSO2407
Created Date
 3-June-2014
Organism
 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
NCBI Taxa ID
 273057
Phosphorylation
Position
Peptide
Code
Type
References
91 EEVLNKIYESVKYAK Y HTP [1]
93 VLNKIYESVKYAKDH S HTP [1]
82 MKYKLKMTKEEVLNK T HTP [1]
96 KIYESVKYAKDHGMI Y HTP [1]
77 TSELHMKYKLKMTKE Y HTP [1]
Reference
 [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus.
 Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC
 J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [PMID:22639831]
Functional Description From UniProt
 FUNCTION: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Amino-acidbiosynthesis; Branched-chainaminoacidbiosynthesis; Completeproteome; Leucinebiosynthesis; Referenceproteome; Transferase
Protein Sequence
 MIARKLADLG VDVIEAGFPA SSEGEFIATR KIFEEIGDQV EVIGLSRSNK NDIDKTISTG 60
 ISSIHLFIAT SELHMKYKLK MTKEEVLNKI YESVKYAKDH GMIVEFSPED ATRTEEDFLF 120
 TAIRTAIEAG ADRINIPDTV GTMHPFKYYD MIKKIVNFVG ERIIVSVHCH NDFGLATANS 180
 LAGVYAGARQ AHVTVNGIGE RAGNASLEEV VMGIKKLLNY ETNVKTWKLY EVSRFVAEMT 240
 GVPVPYFKAI VGDNAFGHES GIHVHGVIEN PFTYEPISPE EVGNFRRLAL GKHSGIHGLR 300
 KLLEEQGIYL SDDKLKIVLA EIKKLAESGN KVTVEDAKNI ALKLMNS 347
  GO:0003852   F:2-isopropylmalate synthase activity IEA:UniProtKB-EC
  GO:0009098   P:leucine biosynthetic process IEA:UniProtKB-UniPathway
  IPR002034   AIPM/Hcit_synth_CS.
  IPR013785   Aldolase_TIM.
  IPR011830   LEU1_arch.
  IPR000891   PYR_CT.
  PF00682   HMGL-like.
  PS00816   AIPM_HOMOCIT_SYNTH_2.
  PS50991   PYR_CT.