| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NAD-dependent protein deacetylase |
Protein Synonyms/Alias | |
Gene Name | cobB |
Gene Synonyms/Alias | SSO2478 |
Created Date | 3-June-2014 |
Organism | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) |
NCBI Taxa ID | 273057 |
Phosphorylation | Position | Peptide | Code | Type | References | | 122 | LHGTMRRSYCVLCLR | S | HTP | [1] | | 123 | HGTMRRSYCVLCLRT | Y | HTP | [1] | |
Reference | [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus. Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [ PMID:22639831] |
Functional Description From UniProt | FUNCTION: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription |
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| Completeproteome; Cytoplasm; Hydrolase; Metal-binding; NAD; Referenceproteome; Transcription; Transcriptionregulation; Zinc |
Protein Sequence | MIYEKVAEEL ISSSYTIAFT GAGISTASGI PDFRGPQGLW KKYSPELASI EYFEKDPKNF 60
WGFYSLRMRG LFEAQPNKAH YSLAELEKMG IIKVIITQNI DGLHQKAGSK NVIELHGTMR 120
RSYCVLCLRT YDSLNVLSMI EKGNLPPRCD CGGIIRPDVV LFGEPVKNIY EALSIAYESD 180
LVISIGSSLT VYPANLIPQT VKERGGKLII LNMEETPLDS IADYVVREPV EISLPKILEN 240
VRQKILS 247 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0070403 F:NAD+ binding IEA:UniProtKB-HAMAP GO:0034979 F:NAD-dependent protein deacetylase activity IEA:UniProtKB-HAMAP GO:0008270 F:zinc ion binding IEA:UniProtKB-HAMAP GO:0006355 P:regulation of transcription, DNA-templated IEA:UniProtKB-KW GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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