※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Methionine aminopeptidase
Protein Synonyms/Alias
 MAP;  MetAP
Gene Name
 map
Gene Synonyms/Alias
 SP_1084
Created Date
 3-June-2014
Organism
 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
NCBI Taxa ID
 170187
Phosphorylation
Position
Peptide
Code
Type
References
126 NVEQMKKYTQSYSGG Y LTP [1]
Reference
 [1]Discovery of a new genetic variant of methionine aminopeptidase from Streptococci with possible post-translational modifications: biochemical and structural characterization.
 Arya T,Kishor C,Saddanapu V,Reddi R,Addlagatta A
 PLoS ONE 2013;8(10):e75207. [PMID:24124477]
Functional Description From UniProt
 FUNCTION: Removes the N-terminal methionine from nascent proteins The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Aminopeptidase; Completeproteome; Hydrolase; Metal-binding; Protease.
Protein Sequence
 MITLKSAREI EAMDKAGDFL ASIHIGLRDL IKPGVDMWEV EEYVRRRCKE ENFLPLQIGV 60
 DGAMMDYPYA TCCSLNDEVA HAFPRHYILK DGDLLKVDMV LGGPIAKSDL NVSKLNFNNV 120
 EQMKKYTQSY SGGLADSCWA YAVGTPSEEV KNLMDVTKEA MYKGIEQAVV GNRIGDIGAA 180
 IQEYAESRGY GVVRDLVGHG VGPTMHEEPM VPNYGIAGRG LRLREGMVLT IEPMINTGDW 240
 EIDTDMKTGW AHKTIDGGLS CQYEHQFVIT KDGPVILTSQ GEEGTY 286
  GO:0046872   F:metal ion binding IEA:UniProtKB-HAMAP
  GO:0070006   F:metalloaminopeptidase activity IEA:UniProtKB-HAMAP
  GO:0070084   P:protein initiator methionine removal IEA:UniProtKB-HAMAP
  IPR000994   Pept_M24_structural-domain.
  IPR002467   Pept_M24A_MAP1.
  PF00557   Peptidase_M24.