※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
Protein Synonyms/Alias
 SEPHCHC synthase
Gene Name
 menD
Gene Synonyms/Alias
 lmo1675
Created Date
 3-June-2014
Organism
 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
NCBI Taxa ID
 169963
Phosphorylation
Position
Peptide
Code
Type
References
33 EAIISPGSRSTPLAL S HTP [1]
Reference
 [1]Analysis of the serine/threonine/tyrosine phosphoproteome of the pathogenic bacterium Listeria monocytogenes reveals phosphorylated proteins related to virulence.
 Misra SK,Milohanic E,Aké F,Mijakovic I,Deutscher J,Monnet V,Henry C
 Proteomics 2011, Nov;11(21):4155-65. [PMID:21956863]
Functional Description From UniProt
 FUNCTION: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Magnesium; Manganese; Menaquinonebiosynthesis; Metal-binding; Referenceproteome; Thiaminepyrophosphate; Transferase
Protein Sequence
 MTNHEQVLTD YLAAFIEELV QAGVKEAIIS PGSRSTPLAL MMAEHPILKI YVDVDERSAG 60
 FFALGLAKAS KRPVVLLCTS GTAAANYFPA VAEANLSQIP LIVLTADRPH ELRNVGAPQA 120
 MDQLHLYGSH VKDFTDMALP ENSEEMLRYA KWHGSRAVDI AMKTPRGPVH LNFPLREPLV 180
 PILEPSPFTA TGKKHHHVHI YYTHEVLDDS SIQKMVTECT GKKGVFVVGP IDKKELEQPM 240
 VDLAKKLGWP ILADPLSGLR SYGALDEVVI DQYDAFLKEA EIMDKLTPEV VIRFGSMPVS 300
 KPLKNWLEQL SDIRFYVVDP GAAWKDPIKA VTDMIHCDER FLLDIMQQNM PDDAKDAAWL 360
 SRWTSYNKVA REIVLAEMAN TTILEEGKIV AELRRLLPEK AGLFIGNSMP IRDVDTYFSQ 420
 IDKKIKMLAN RGANGIDGVV SSALGASVVF QPMFLLIGDL SFYHDMNGLL MAKKYKMNLT 480
 IVIVNNDGGG IFSFLPQANE PKYFESLFGT STELDFRFAA AFYDADYHET QSVDELEEAI 540
 DKASYHKGLD IIEVKTNRHE NKANHQALWA KIADALKALN 580
  GO:0070204   F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity IEA:UniProtKB-EC
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0030976   F:thiamine pyrophosphate binding IEA:InterPro
  GO:0009234   P:menaquinone biosynthetic process IEA:UniProtKB-UniPathway
  IPR004433   MenaQ_synth_MenD.
  IPR012001   Thiamin_PyroP_enz_TPP-bd_dom.
  IPR011766   TPP_enzyme-bd_C.
  PF02775   TPP_enzyme_C.
  PF02776   TPP_enzyme_N.