※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isoleucine--tRNA ligase
Protein Synonyms/Alias
 IleRS
Gene Name
 ileS
Gene Synonyms/Alias
 lmo2019
Created Date
 3-June-2014
Organism
 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
NCBI Taxa ID
 169963
Phosphorylation
Position
Peptide
Code
Type
References
597 EGRKMSKSLGNTLLP S HTP [1]
Reference
 [1]Analysis of the serine/threonine/tyrosine phosphoproteome of the pathogenic bacterium Listeria monocytogenes reveals phosphorylated proteins related to virulence.
 Misra SK,Milohanic E,Aké F,Mijakovic I,Deutscher J,Monnet V,Henry C
 Proteomics 2011, Nov;11(21):4155-65. [PMID:21956863]
Functional Description From UniProt
 FUNCTION: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; Referenceproteome; Zinc
Protein Sequence
 MEYKDTLLMP KTDFPMRGNL PNKEPEWQAK WEEEKLYEKI QEKNAGRPTY ILHDGPPYAN 60
 GELHMGHALN KTIKDIIVRY KSMAGFSSPY VPGWDTHGLP IETAIAKKGV KRKEMSIAEF 120
 RKLCAEYAMK QVDGQRTGFK RLGINGDWEN PYITLLPEYE AEQIKVFGEM AKKGYIYKGK 180
 KPVYWSPSSE SALAEAEIEY QDKTSASIFV AFKVTDGKGV LDEGTNIVIW TTTPWTIPAN 240
 MGITVNPDLD YVVIESAGEK YVVAEALLPS LREKLGFEDA TVVKTVRGSE LDRVVTKHPF 300
 YDRDSLVMNG EHATAEAGTG AVHTAPGHGE DDFLIGKKYD LEILAPLDDR GVFTEEAPGF 360
 EGVFYDTANK MVTEKLEEVG ALLKMEFITH SYPHDWRTKK PVIFRATAQW FASIDAFRDD 420
 LLAAVKGVNW TPAWGETRLF NMVRDRGDWV ISRQRAWGVP LPIFYAENGE AIITDETINH 480
 ISELFREHGS NVWFERDVKD LLPAGFTHPG SPNGEFTKET DIMDVWFDSG SSHQAVLNAR 540
 PELSRPADLY MEGSDQYRGW FNSSLTTAVA ITGEAPYRNV LSHGFALDGE GRKMSKSLGN 600
 TLLPGKVIKQ LGADIVRLWV ASVDYQADVR VSDEILKQVS EVYRKIRNTM RFLLGNINDF 660
 NPTTNTVSYE NLREVDKYML IKLNDLVKNV KDSYEAFEFS TIYHQINNFC TVELSQFYMD 720
 FAKDVVYIEA ADSHDRRAMQ TVFYEAVVTL TKLLAPILPH TTEEVWNSLI GEGAESIHLQ 780
 DLPDVKVLAN SEEITAKWDA FMQIRDNVQK ALEFARNEKL IGKSMLAKVT LYVDGEAKTL 840
 FDSLEGDFAQ LFIVSDFELV EGLENAPESA FKSNQVAVQI TVAEGETCER CRVVKKDVGV 900
 NPKHPTLCGR CADIVVKHYE A 921
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0002161   F:aminoacyl-tRNA editing activity IEA:InterPro
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0004822   F:isoleucine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006428   P:isoleucyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR001412   aa-tRNA-synth_I_CS.
  IPR002300   aa-tRNA-synth_Ia.
  IPR002301   Ile-tRNA-ligase.
  IPR023585   Ile-tRNA-ligase_type1.
  IPR014729   Rossmann-like_a/b/a_fold.
  IPR009080   tRNAsynth_1a_anticodon-bd.
  IPR013155   V/L/I-tRNA-synth_anticodon-bd.
  IPR009008   Val/Leu/Ile-tRNA-synth_edit.
  IPR010663   Znf_DNA_glyclase/IsotRNA_synth.
  PF08264   Anticodon_1.
  PF00133   tRNA-synt_1.
  PF06827   zf-FPG_IleRS.
  PS00178   AA_TRNA_LIGASE_I.
  PR00984   TRNASYNTHILE.