| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine hydroxymethyltransferase |
Protein Synonyms/Alias | SHMT; Serine methylase |
Gene Name | glyA |
Gene Synonyms/Alias | Z3827, ECs3417 |
Created Date | 3-June-2014 |
Organism | Escherichia coli O157:H7 |
NCBI Taxa ID | 83334 |
Phosphorylation | Position | Peptide | Code | Type | References | | 55 | GSQLTNKYAEGYPGK | Y | HTP | [1] | | 11 | REMNIADYDAELWQA | Y | HTP | [1] | | 59 | TNKYAEGYPGKRYYG | Y | HTP | [1] | | 177 | IIGGFSAYSGVVDWA | Y | HTP | [1] | |
Reference | [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence. Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A PLoS Pathog. 2013;9(6):e1003403. [ PMID:23785281] |
Functional Description From UniProt | FUNCTION: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) |
| MOD_RES 54 54 N6-acetyllysine (By similarity)
MOD_RES 229 229 N6-(pyridoxal phosphate)lysine (By similarity)
MOD_RES 250 250 N6-acetyllysine (By similarity)
MOD_RES 285 285 N6-acetyllysine (By similarity)
MOD_RES 354 354 N6-acetyllysine (By similarity)
MOD_RES 375 375 N6-acetyllysine (By similarity) |
| Acetylation; Amino-acidbiosynthesis; Completeproteome; Cytoplasm; One-carbonmetabolism; Pyridoxalphosphate; Transferase |
Protein Sequence | MLKREMNIAD YDAELWQAME QEKVRQEEHI ELIASENYTS PRVMQAQGSQ LTNKYAEGYP 60
GKRYYGGCEY VDIVEQLAID RAKELFGADY ANVQPHSGSQ ANFAVYTALL EPGDTVLGMN 120
LAHGGHLTHG SPVNFSGKLY NIVPYGIDAT GHIDYADLEK QAKEHKPKMI IGGFSAYSGV 180
VDWAKMREIA DSIGAYLFVD MAHVAGLVAA GVYPNPVPHA HVVTTTTHKT LAGPRGGLIL 240
AKGGSEELYK KLNSAVFPGG QGGPLMHVIA GKAVALKEAM EPEFKTYQQQ VAKNAKAMVE 300
VFLERGYKVV SGGTDNHLFL VDLVDKNLTG KEADAALGRA NITVNKNSVP NDPKSPFVTS 360
GIRVGTPAIT RRGFKEVEAK ELAGWMCDVL DSINDEAVIE RIKGKVLDIC ARYPVYA 417 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0004372 F:glycine hydroxymethyltransferase activity IEA:UniProtKB-HAMAP GO:0030170 F:pyridoxal phosphate binding IEA:UniProtKB-HAMAP GO:0019264 P:glycine biosynthetic process from serine IEA:UniProtKB-HAMAP GO:0035999 P:tetrahydrofolate interconversion IEA:UniProtKB-UniPathway |
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