※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Biotin synthase
Protein Synonyms/Alias
 
Gene Name
 bioB
Gene Synonyms/Alias
 Z0994, ECs0853
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
161 LDTSPEFYGNIITTR Y HTP [1]
59 ACPEDCKYCPQSSRY Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 2Fe-2S; 4Fe-4S; Biotinbiosynthesis; Completeproteome; Iron; Iron-sulfur; Metal-binding; S-adenosyl-L-methionine; Transferase
Protein Sequence
 MAHRPRWTLS QVTELFEKPL LDLLFEAQQV HRQHFDPRQV QVSTLLSIKT GACPEDCKYC 60
 PQSSRYKTGL EAERLMEVEQ VLESARKAKA AGSTRFCMGA AWKNPHERDM SYLEQMVQGV 120
 KAMGLEACMT LGTLSESQAQ RLANAGLDYY NHNLDTSPEF YGNIITTRTY QERLDTLEKV 180
 RDAGIKVCSG GIVGLGETVK DRAGLLLQLA NLPTPPESVP INMLVKVKGT PLADNDDVDA 240
 FDFIRTIAVA RIMMPTSYVR LSAGREQMNE QTQAMCFMAG ANSIFYGCKL LTTPNPEEDK 300
 DLQLFRKLGL NPQQTAVLAG DNEQQQRLEQ ALMTPDTDEY YNAAAL 346
  GO:0051537   F:2 iron, 2 sulfur cluster binding IEA:UniProtKB-KW
  GO:0051539   F:4 iron, 4 sulfur cluster binding IEA:UniProtKB-KW
  GO:0004076   F:biotin synthase activity IEA:UniProtKB-HAMAP
  GO:0005506   F:iron ion binding IEA:UniProtKB-HAMAP
  GO:0009102   P:biotin biosynthetic process IEA:UniProtKB-HAMAP
  IPR013785   Aldolase_TIM.
  IPR010722   BATS_dom.
  IPR002684   Biotin_synth/BioAB.
  IPR024177   Biotin_synthase.
  IPR006638   Elp3/MiaB/NifB.
  IPR007197   rSAM.
  PF06968   BATS.
  PF04055   Radical_SAM.
  SM00876   BATS.
  SM00729   Elp3.