※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA translocase FtsK
Protein Synonyms/Alias
 
Gene Name
 ftsK
Gene Synonyms/Alias
 Z1235, ECs0975
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
663 AQTQQQRYGEQYQHD Y HTP [1]
280 DDDEEITYTARGVAA Y HTP [1]
667 QQRYGEQYQHDVPVN Y HTP [1]
223 EYEDDEEYEDENHGK Y HTP [1]
5 ***MSQEYTEDKEVT Y HTP [1]
217 TWVDEDEYEDDEEYE Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity)
Sequence Annotation From UniProt
 TRANSMEM 22 42 Helical; (Potential)
 TRANSMEM 76 96 Helical; (Potential)
 TRANSMEM 112 132 Helical; (Potential)
 TRANSMEM 137 157 Helical; (Potential)
 TRANSMEM 164 184 Helical; (Potential)
Key Word From UniProt
 ATP-binding; Cellcycle; Celldivision; Cellinnermembrane; Cellmembrane; Chromosomepartition; Completeproteome; DNA-binding; Membrane; Nucleotide-binding; Transmembrane; Transmembranehelix
Protein Sequence
 MSQEYTEDKE VTLTKLSSGR RLLEALLILI VLFAVWLMAA LLSFNPSDPS WSQTAWHEPI 60
 HNLGGMPGAW LADTLFFIFG VMAYTIPVII VGGCWFAWRH QSSDENIDYF AVSLRIIGVL 120
 ALILTSCGLA AINADDIWYF ASGGVIGSLL STTLQPLLHS SGGTIALLCV WAAGLTLFTG 180
 WSWVTIAEKL GGWILNILTF ASNRTRRDDT WVDEDEYEDD EEYEDENHGK QHESRRARIL 240
 RGALARRKRL AEKFINPMGR QTDAALFSGK RMDDDEEITY TARGVAADPD DVLFSGNRAT 300
 QPEYDEYDPL LNGAPITEPV AVAAAATTAT QSWAAPVEPV TQTPPVASVD VPPSQPTVAW 360
 QPVPGPQTGE PVIAPAPEGY PQQSQYAQPA VQYNEPLQQP VQPQQPYYAP AAEQPAQQPY 420
 YAPAPEQPVA GNAWQAEEQQ STFAPQSTYQ TEQTYQQPAA QEPLYQQPQP VEQQPVVEPE 480
 PVVEETKPAR PPLYYFEEVE EKRAREREQL AAWYQPIPEP VKEPEPIKSS LKAPSVAAVP 540
 PVEAAAAVSP LASGVKKATL ATGAAATVAA PVFSLANSGG PRPQVKEGIG PQLPRPKRIR 600
 VPTRRELASY GIKLPSQRAA EEKAREAQRN QYDSGDQYND DEIDAMQQDE LARQFAQTQQ 660
 QRYGEQYQHD VPVNAEDADA AAEAELARQF AQTQQQRYSG EQPAGANPFS LDDFEFSPMK 720
 ALLDDGPHEP LFTPIVEPVQ QPQQPVAPQQ QYQQPQQPVA PQPQYQQPQQ QVAPQPQYQQ 780
 PQQPVAPQQQ YQQPQQPVAP QPQYQQPQQP VAPQPQYQQP QQPVAPQPQD TLLHPLLMRN 840
 GDSRPLHKPT TPLPSLDLLT PPPSEVEPVD TFALEQMARL VEARLADFRI KADVVNYSPG 900
 PVITRFELNL APGVKAARIS NLSRDLARSL STVAVRVVEV IPGKPYVGLE LPNKKRQTVY 960
 LREVLDNAKF RDNPSPLTVV LGKDIAGEPV VADLAKMPHL LVAGTTGSGK SVGVNAMILS 1020
 MLYKAQPEDV RFIMIDPKML ELSVYEGIPH LLTEVVTDMK DAANALRWCV NEMERRYKLM 1080
 SALGVRNLAG YNEKIAEADR MMRPIPDPYW KPGDSMDAQH PVLKKEPYIV VLVDEFADLM 1140
 MTVGKKVEEL IARLAQKARA AGIHLVLATQ RPSVDVITGL IKANIPTRIA FTVSSKIDSR 1200
 TILDQAGAES LLGMGDMLYS GPNSTLPVRV HGAFVRDQEV HAVVQDWKAR GRPQYVDGIT 1260
 SDSESEGGAG GFDGAEELDP LFDQAVQFVT EKRKASISGV QRQFRIGYNR AARIIEQMEA 1320
 QGIVSEQGHN GNREVLSPPP FD 1342
  GO:0016021   C:integral component of membrane IEA:UniProtKB-KW
  GO:0005886   C:plasma membrane IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-KW
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0007049   P:cell cycle IEA:UniProtKB-KW
  GO:0051301   P:cell division IEA:UniProtKB-KW
  GO:0007059   P:chromosome segregation IEA:UniProtKB-KW
  IPR002543   Cell_div_FtsK/SpoIIIE.
  IPR018541   DNA_translocase_Ftsk_gamma.
  IPR025199   DUF4117.
  IPR027417   P-loop_NTPase.
  PF13491   DUF4117.
  PF09397   Ftsk_gamma.
  PF01580   FtsK_SpoIIIE.
  SM00843   Ftsk_gamma.
  PS50901   FTSK.