※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fumarate hydratase class I, aerobic
Protein Synonyms/Alias
 Fumarase
Gene Name
 fumA
Gene Synonyms/Alias
 Z2615, ECs2318
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
431 PAKTPEGYASGSLGP Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: It functions as an aerobic enzyme in the citric acid cycle. It accounts for about 80% of the fumarase activity when the bacteria grows aerobically (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 4Fe-4S; Completeproteome; Iron; Iron-sulfur; Lyase; Metal-binding; Tricarboxylicacidcycle
Protein Sequence
 MSNKPFHYQA PFPLKKDDTE YYLLTSEHVS LSEFEGQEIL KVAPEALTLL ARQAFHDASF 60
 MLRPAHQQQV ADILRDPEAS ENDKYVALQF LRNSDIAAKG VLPTCQDTGT AIIVGKKGQR 120
 VWTGGGDEAA LARGVYNTYI EDNLRYSQNA PLDMYKEVNT GTNLPAQIDL YAVDGDEYKF 180
 LCIAKGGGSA NKTYLYQETK ALLTPGKLKN YLVEKMRTLG TAACPPYHIA FVIGGTSAET 240
 NLKTVKLASA KYYDELPTEG NEHGQAFRDV ELEKELLIEA QNLGLGAQFG GKYFAHDIRV 300
 IRLPRHGASC PVGMGVSCSA DRNIKAKINR QGIWIEKLEH NPGKYIPEEL RKAGEGEAVR 360
 VDLNRPMKEI LAQLSQYPVS TRLSLNGTII VGRDIAHAKL KERMDNGEGL PQYIKDHPIY 420
 YAGPAKTPEG YASGSLGPTT AGRMDSYVDQ LQALGGSMIM LAKGNRSQQV TDACKKHGGF 480
 YLGSIGGPAA VLAQGSIKSL ECVEYPELGM EAIWKIEVED FPAFILVDDK GNDFFQQIQL 540
 TQCTRCVK 548
  GO:0051539   F:4 iron, 4 sulfur cluster binding IEA:UniProtKB-KW
  GO:0004333   F:fumarate hydratase activity IEA:UniProtKB-EC
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0006099   P:tricarboxylic acid cycle IEA:UniProtKB-UniPathway
  IPR004646   Fe-S_hydro-lyase_TtdA-typ_cat.
  IPR004647   Fe-S_hydro-lyase_TtdB-typ_cat.
  IPR011167   Fe_dep_fumarate_hydratase.
  IPR020557   Fumarate_lyase_CS.
  PF05681   Fumerase.
  PF05683   Fumerase_C.
  PS00163   FUMARATE_LYASES.