※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alanine--tRNA ligase
Protein Synonyms/Alias
 AlaRS
Gene Name
 alaS
Gene Synonyms/Alias
 Z3999, ECs3554
Created Date
 3-June-2014
Organism
 Escherichia coli O157:H7
NCBI Taxa ID
 83334
Phosphorylation
Position
Peptide
Code
Type
References
446 ASGFGADYNAMIRVD Y HTP [1]
649 MALFGEKYDERVRVL Y HTP [1]
Reference
 [1]The Escherichia coli phosphotyrosine proteome relates to core pathways and virulence.
 Hansen AM,Chaerkady R,Sharma J,Díaz-Mejía JJ,Tyagi N,Renuse S,Jacob HK,Pinto SM,Sahasrabuddhe NA,Kim MS,Delanghe B,Srinivasan N,Emili A,Kaper JB,Pandey A
 PLoS Pathog. 2013;9(6):e1003403. [PMID:23785281]
Functional Description From UniProt
 FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Sequence Annotation From UniProt
 MOD_RES 74 74 N6-acetyllysine (By similarity)
Key Word From UniProt
 Acetylation; Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; RNA-binding; tRNA-binding; Zinc
Protein Sequence
 MSKSTAEIRQ AFLDFFHSKG HQVVASSSLV PHNDPTLLFT NAGMNQFKDV FLGLDKRNYS 60
 RATTSQRCVR AGGKHNDLEN VGYTARHHTF FEMLGNFSFG DYFKHDAIQF AWELLTSEKW 120
 FALPKERLWV TVYESDDEAY EIWEKEVGIP RERIIRIGDN KGAPYASDNF WQMGDTGPCG 180
 PCTEIFYDHG DHIWGGPPGS PEEDGDRYIE IWNIVFMQFN RQADGTMEPL PKPSVDTGMG 240
 LERIAAVLQH VNSNYDIDLF RTLIQAVAKV TGATDLSNKS LRVIADHIRS CAFLIADGVM 300
 PSNENRGYVL RRIIRRAVRH GNMLGAKETF FYKLVGPLID VMGSAGEDLK RQQAQVEQVL 360
 KTEEEQFART LERGLALLDE ELAKLSGDTL DGETAFRLYD TYGFPVDLTA DVCRERNIKV 420
 DEAGFEAAME EQRRRAREAS GFGADYNAMI RVDSASEFKG YDHLELNGKV TALFVDGKAV 480
 DAINAGQEAV VVLDQTPFYA ESGGQVGDKG ELKGANFSFV VEDTQKYGQA IGHIGKLAAG 540
 SLKVGDAVQA DVDEARRARI RLNHSATHLM HAALRQVLGT HVSQKGSLVN DKVLRFDFSH 600
 NEAMKPEEIR AVEDLVNAQI RRNLPIETNI MDLEAAKAKG AMALFGEKYD ERVRVLSMGD 660
 FSTELCGGTH ASRTGDIGLF RIISESGTAA GVRRIEAVTG EGAITTVHAD SDRLSEVAHL 720
 LKGDSNNLAD KVRSVLERTR QLEKELQQLK EQAAAQESAN LSSKAIDVNG VKLLVSELSG 780
 VEPKMLRTMV DDLKNQLGST IIVLATVAEG KVSLIAGVSK DVTDRVKAGE LIGMVAQQVG 840
 GKGGGRPDMA QAGGTDAAAL PAALASVKGW VSAKLQ 876
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004813   F:alanine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0000049   F:tRNA binding IEA:UniProtKB-KW
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006419   P:alanyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR002318   Ala-tRNA-lgiase_IIc.
  IPR018162   Ala-tRNA-ligase_IIc_anticod-bd.
  IPR018165   Ala-tRNA-synth_IIc_core.
  IPR018164   Ala-tRNA-synth_IIc_N.
  IPR023033   Ala_tRNA_ligase_euk/bac.
  IPR003156   Pesterase_DHHA1.
  IPR018163   Thr/Ala-tRNA-synth_IIc_edit.
  IPR009000   Transl_B-barrel.
  IPR012947   tRNA_SAD.
  PF02272   DHHA1.
  PF01411   tRNA-synt_2c.
  PF07973   tRNA_SAD.
  SM00863   tRNA_SAD.
  PS50860   AA_TRNA_LIGASE_II_ALA.
  PR00980   TRNASYNTHALA.