※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 LexA repressor
Protein Synonyms/Alias
 
Gene Name
 lexA
Gene Synonyms/Alias
 LA_1447
Created Date
 3-June-2014
Organism
 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
NCBI Taxa ID
 189518
Phosphorylation
Position
Peptide
Code
Type
References
43 GITAKGAYDHLKAIE Y HTP [1]
45 TAKGAYDHLKAIEKK H HTP [1]
44 ITAKGAYDHLKAIEK D HTP [1]
Reference
 [1]High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans.
 Cao XJ,Dai J,Xu H,Nie S,Chang X,Hu BY,Sheng QH,Wang LS,Ning ZB,Li YX,Guo XK,Zhao GP,Zeng R
 Cell Res. 2010, Feb;20(2):197-210. [PMID:19918266]
Functional Description From UniProt
 FUNCTION: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Autocatalyticcleavage; Completeproteome; DNAdamage; DNArepair; DNAreplication; DNA-binding; Hydrolase; Referenceproteome; Repressor; SOSresponse; Transcription; Transcriptionregulation
Protein Sequence
 MKDLTDKQQA VLAFITAIIK ERGFPPTIRE IGDEFGITAK GAYDHLKAIE KKGYLKTAKN 60
 QSRAIELIRQ SPMESLPVQA TSIPVIGQVA AGLPIFAEEN IESYIPVPDE MAKGNVPMYA 120
 LRVQGDSMIE VGINDGDIAI IEKRDIARNG EIVVALIEDE ATLKVYYKEQ DQIRLEARNP 180
 KYKPIKTKKA TVMGKLIGLY RIY 203
  GO:0003677   F:DNA binding IEA:UniProtKB-HAMAP
  GO:0004252   F:serine-type endopeptidase activity IEA:UniProtKB-HAMAP
  GO:0006281   P:DNA repair IEA:UniProtKB-HAMAP
  GO:0006260   P:DNA replication IEA:UniProtKB-HAMAP
  GO:0045892   P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP
  GO:0009432   P:SOS response IEA:UniProtKB-HAMAP
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR006200   LexA.
  IPR006199   LexA_DNA-bd_dom.
  IPR028360   Peptidase_S24/S26_b-rbn.
  IPR006197   Peptidase_S24_LexA.
  IPR019759   Peptidase_S24_S26.
  IPR015927   Peptidase_S24_S26A/B/C.
  IPR011991   WHTH_DNA-bd_dom.
  PF01726   LexA_DNA_bind.
  PF00717   Peptidase_S24.
  PR00726   LEXASERPTASE.