Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | LexA repressor |
Protein Synonyms/Alias | |
Gene Name | lexA |
Gene Synonyms/Alias | LA_1447 |
Created Date | 3-June-2014 |
Organism | Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) |
NCBI Taxa ID | 189518 |
Phosphorylation | Position | Peptide | Code | Type | References | 43 | GITAKGAYDHLKAIE | Y | HTP | [1] | 45 | TAKGAYDHLKAIEKK | H | HTP | [1] | 44 | ITAKGAYDHLKAIEK | D | HTP | [1] | |
Reference | [1]High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans. Cao XJ,Dai J,Xu H,Nie S,Chang X,Hu BY,Sheng QH,Wang LS,Ning ZB,Li YX,Guo XK,Zhao GP,Zeng R Cell Res. 2010, Feb;20(2):197-210. [ PMID:19918266] |
Functional Description From UniProt | FUNCTION: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) |
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| Autocatalyticcleavage; Completeproteome; DNAdamage; DNArepair; DNAreplication; DNA-binding; Hydrolase; Referenceproteome; Repressor; SOSresponse; Transcription; Transcriptionregulation |
Protein Sequence | MKDLTDKQQA VLAFITAIIK ERGFPPTIRE IGDEFGITAK GAYDHLKAIE KKGYLKTAKN 60 QSRAIELIRQ SPMESLPVQA TSIPVIGQVA AGLPIFAEEN IESYIPVPDE MAKGNVPMYA 120 LRVQGDSMIE VGINDGDIAI IEKRDIARNG EIVVALIEDE ATLKVYYKEQ DQIRLEARNP 180 KYKPIKTKKA TVMGKLIGLY RIY 203 |
| GO:0003677 F:DNA binding IEA:UniProtKB-HAMAP GO:0004252 F:serine-type endopeptidase activity IEA:UniProtKB-HAMAP GO:0006281 P:DNA repair IEA:UniProtKB-HAMAP GO:0006260 P:DNA replication IEA:UniProtKB-HAMAP GO:0045892 P:negative regulation of transcription, DNA-templated IEA:UniProtKB-HAMAP GO:0009432 P:SOS response IEA:UniProtKB-HAMAP GO:0006351 P:transcription, DNA-templated IEA:UniProtKB-KW |
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