※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-adenosylmethionine synthase
Protein Synonyms/Alias
 AdoMet synthase
Gene Name
 metK
Gene Synonyms/Alias
 LA_2633
Created Date
 3-June-2014
Organism
 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
NCBI Taxa ID
 189518
Phosphorylation
Position
Peptide
Code
Type
References
304 KCEVQLAYAIGVAEP Y HTP [1]
Reference
 [1]High-coverage proteome analysis reveals the first insight of protein modification systems in the pathogenic spirochete Leptospira interrogans.
 Cao XJ,Dai J,Xu H,Nie S,Chang X,Hu BY,Sheng QH,Wang LS,Ning ZB,Li YX,Guo XK,Zhao GP,Zeng R
 Cell Res. 2010, Feb;20(2):197-210. [PMID:19918266]
Functional Description From UniProt
 FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 ATP-binding; Cobalt; Completeproteome; Cytoplasm; Magnesium; Metal-binding; Nucleotide-binding; One-carbonmetabolism; Potassium; Referenceproteome; Transferase
Protein Sequence
 MSLKDFIFTS ESVGEGHPDK VCDQISDAVL DAYLEQDPKS RVACETLVTT NLVVIAGEIT 60
 SKGKVDAQEI ARNVIRDIGY NDITMGFDAD FAVVSAHVHA QSPDISQGVT EGEGLFKEQG 120
 AGDQGLMFGF AINETPELMP MPIYYSHELV KHLAGLRHGN KLKFLRPDAK SQVTVEYKDG 180
 KPVRIDTVVI STQHSPDVTH KQIEEALIEE CIKKVIPANL LNNTKYFINP TGQFIIGGPH 240
 GDAGLTGRKI IVDTYGGYGR HGGGAFSGKD PSKVDRSAAY MGRYIAKNVV ASGLADKCEV 300
 QLAYAIGVAE PVSVHVDTFG TGKISEEELV KRIRANFKLT PRGIIESLKL LEKGRKYRET 360
 ASYGHFGRKG STFTWEETDK ASALKG 386
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0004478   F:methionine adenosyltransferase activity IEA:UniProtKB-HAMAP
  GO:0006730   P:one-carbon metabolic process IEA:UniProtKB-HAMAP
  GO:0006556   P:S-adenosylmethionine biosynthetic process IEA:UniProtKB-UniPathway
  IPR022631   ADOMET_SYNTHASE_CS.
  IPR022630   S-AdoMet_synt_C.
  IPR022629   S-AdoMet_synt_central.
  IPR022628   S-AdoMet_synt_N.
  IPR002133   S-AdoMet_synthetase.
  IPR022636   S-AdoMet_synthetase_sfam.
  PF02773   S-AdoMet_synt_C.
  PF02772   S-AdoMet_synt_M.
  PF00438   S-AdoMet_synt_N.
  PS00376   ADOMET_SYNTHASE_1.
  PS00377   ADOMET_SYNTHASE_2.