※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anti-sigma factor RsrA
Protein Synonyms/Alias
 
Gene Name
 rsrA
Gene Synonyms/Alias
 SCO5217
Created Date
 3-June-2014
Organism
 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
NCBI Taxa ID
 100226
Phosphorylation
Position
Peptide
Code
Type
References
105 SSSAPQES******* S HTP [1]
Reference
 [1]Phosphoproteome analysis of Streptomyces development reveals extensive protein phosphorylation accompanying bacterial differentiation.
 Manteca A,Ye J,Sánchez J,Jensen ON
 J. Proteome Res. 2011, Dec, 2;10(12):5481-92. [PMID:21999169]
Functional Description From UniProt
 FUNCTION: A redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigR, and a key sensor of disulfide stress. Holds SigR, its cognate ECF sigma factor, in an inactive form, inhibiting its sigma activity under reducing but not oxidizing conditions; oxidation and reduction of the anti-sigma factor is reversible. Mycothiol (MSH) is competent for reduction of RsrA, allowing it to bind to SigR. In conjunction with its cognate sigma factor SigR may sense the intracellular level of reduced MSH. Probably releases SigR during oxidative stress
Sequence Annotation From UniProt
 DISULFID 11 44 Or C-11 with C-41 (about 25%)
Key Word From UniProt
 Completeproteome; Disulfidebond; Metal-binding; Redox-activecenter; Referenceproteome; Sporulation; Transcription; Transcriptionregulation; Zinc
Protein Sequence
 MSCGEPHETD CSEILDHLYE FLDKEMPDSD CVKFEHHFEE CSPCLEKYGL EQAVKKLVKR 60
 CCGQDDVPGD LRAKVMGRLD LIRSGQSVPE HDVAAAPSSS APQES 105
  GO:0016989   F:sigma factor antagonist activity IDA:UniProtKB
  GO:0008270   F:zinc ion binding IMP:UniProtKB
  GO:0051776   P:detection of redox state IMP:UniProtKB
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0051775   P:response to redox state IDA:UniProtKB
  GO:0043934   P:sporulation IMP:UniProtKB
  GO:0030435   P:sporulation resulting in formation of a cellular spore IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR024020   Anit_sigma_micothiol_RsrA.
  IPR014295   Anti-sigma.
  IPR027383   Znf_put.
  PF13490   zf-HC2.