※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Circadian clock protein kinase KaiC
Protein Synonyms/Alias
 
Gene Name
 kaiC
Gene Synonyms/Alias
 Synpcc7942_1216; ORFNames=see0011
Created Date
 3-June-2014
Organism
 Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
NCBI Taxa ID
 1140
Phosphorylation
Position
Peptide
Code
Type
References
431 SITDSHISTITDTII S LTP [1]
426 FMGAHSITDSHISTI T LTP [2]
432 ITDSHISTITDTIIL T NA UniProt
Reference
 [1]Identification of key phosphorylation sites in the circadian clock protein KaiC by crystallographic and mutagenetic analyses.
 Xu Y,Mori T,Pattanayek R,Pattanayek S,Egli M,Johnson CH
 Proc. Natl. Acad. Sci. U.S.A. 2004, Sep, 21;101(38):13933-8. [PMID:15347809]
 [2]Structures of KaiC circadian clock mutant proteins: a new phosphorylation site at T426 and mechanisms of kinase, ATPase and phosphatase.
 Pattanayek R,Mori T,Xu Y,Pattanayek S,Johnson CH,Egli M
 PLoS ONE 2009;4(11):e7529. [PMID:19956664]
Functional Description From UniProt
 FUNCTION: Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Sequence Annotation From UniProt
 MOD_RES 432 432 Phosphothreonine; by autocatalysis
Key Word From UniProt
 3D-structure; ATP-binding; Biologicalrhythms; Completeproteome; DNA-binding; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Repeat; Repressor; Serine/threonine-proteinkinase; Transcription; Transcriptionregulation; Transferase
Protein Sequence
 MTSAEMTSPN NNSEHQAIAK MRTMIEGFDD ISHGGLPIGR STLVSGTSGT GKTLFSIQFL 60
 YNGIIEFDEP GVFVTFEETP QDIIKNARSF GWDLAKLVDE GKLFILDASP DPEGQEVVGG 120
 FDLSALIERI NYAIQKYRAR RVSIDSVTSV FQQYDASSVV RRELFRLVAR LKQIGATTVM 180
 TTERIEEYGP IARYGVEEFV SDNVVILRNV LEGERRRRTL EILKLRGTSH MKGEYPFTIT 240
 DHGINIFPLG AMRLTQRSSN VRVSSGVVRL DEMCGGGFFK DSIILATGAT GTGKTLLVSR 300
 FVENACANKE RAILFAYEES RAQLLRNAYS WGMDFEEMER QNLLKIVCAY PESAGLEDHL 360
 QIIKSEINDF KPARIAIDSL SALARGVSNN AFRQFVIGVT GYAKQEEITG LFTNTSDQFM 420
 GAHSITDSHI STITDTIILL QYVEIRGEMS RAINVFKMRG SWHDKAIREF MISDKGPDIK 480
 DSFRNFERII SGSPTRITVD EKSELSRIVR GVQEKGPES 519
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0042802   F:identical protein binding IPI:IntAct
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  GO:0004712   F:protein serine/threonine/tyrosine kinase activity IEA:UniProtKB-HAMAP
  GO:0007623   P:circadian rhythm IEA:UniProtKB-HAMAP
  GO:0009649   P:entrainment of circadian clock IDA:UniProtKB
  GO:0042754   P:negative regulation of circadian rhythm TAS:UniProtKB
  GO:0070297   P:regulation of phosphorelay signal transduction system IDA:CACAO
  GO:0006355   P:regulation of transcription, DNA-templated IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR014774   Circ_KaiC/RadA.
  IPR013503   Circadian_KaiC.
  IPR010624   KaiC_dom.
  IPR027417   P-loop_NTPase.
  PF06745   KaiC.
  PS51146   KAIC.