※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Formamidopyrimidine-DNA glycosylase
Protein Synonyms/Alias
 Fapy-DNA glycosylase
Gene Name
 mutM
Gene Synonyms/Alias
 fpg; OrderedLocusNames=SYNPCC7002_A1816
Created Date
 3-June-2014
Organism
 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
NCBI Taxa ID
 32049
Phosphorylation
Position
Peptide
Code
Type
References
61 DWQRRGKYLLGKLSD Y HTP [1]
Reference
 [1]Global phosphoproteomic analysis reveals diverse functions of serine/threonine/tyrosine phosphorylation in the model cyanobacterium Synechococcus sp. strain PCC 7002.
 Yang MK,Qiao ZX,Zhang WY,Xiong Q,Zhang J,Li T,Ge F,Zhao JD
 J. Proteome Res. 2013, Apr, 5;12(4):1909-23. [PMID:23461524]
Functional Description From UniProt
 FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; DNAdamage; DNArepair; DNA-binding; Glycosidase; Hydrolase; Lyase; Metal-binding; Multifunctionalenzyme; Zinc; Zinc-finger
Protein Sequence
 MPELPEVETV RRGLMQISLN QQFTGAEILL RKTLAYPTDP DHFLGMIQGL FIQDWQRRGK 60
 YLLGKLSDGS TLGIHLRMTG KFLWTTPDVP VQKHTRIRFF IEGDRELRFV DLRTFGQIWW 120
 VPAGTIVKSV ITGLTRLGVE PLSPDFTADL LANFCEKRQR PMKTFLLDQS IITGLGNIYA 180
 DEALFKSGIH PTRKASSLKM SEIEKLHKAI VEVLETSIAQ GGTTFSDFVS TTGTNGNYGG 240
 MALTYGRTGE PCRVCSHPIE RIKLGGRSTH FCPQCQS 277
  GO:0003684   F:damaged DNA binding IEA:InterPro
  GO:0008534   F:oxidized purine nucleobase lesion DNA N-glycosylase activity IEA:UniProtKB-HAMAP
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006284   P:base-excision repair IEA:InterPro
  GO:0006289   P:nucleotide-excision repair IEA:InterPro
  IPR015886   DNA_glyclase/AP_lyase_DNA-bd.
  IPR015887   DNA_glyclase_Znf_dom_DNA_BS.
  IPR000191   DNA_glycosylase/AP_lyase.
  IPR012319   DNA_glycosylase/AP_lyase_cat.
  IPR020629   Formamido-pyr_DNA_Glyclase.
  IPR010979   Ribosomal_S13-like_H2TH.
  IPR000214   Znf_DNA_glyclase/AP_lyase.
  IPR010663   Znf_DNA_glyclase/IsotRNA_synth.
  PF01149   Fapy_DNA_glyco.
  PF06831   H2TH.
  PF06827   zf-FPG_IleRS.
  SM00898   Fapy_DNA_glyco.
  PS51068   FPG_CAT.
  PS01242   ZF_FPG_1.
  PS51066   ZF_FPG_2.