※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase 1
Protein Synonyms/Alias
 SHMT 1;  Serine methylase 1
Gene Name
 glyA1
Gene Synonyms/Alias
 RPA2724
Created Date
 3-June-2014
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
NCBI Taxa ID
 258594
Phosphorylation
Position
Peptide
Code
Type
References
17 PDSFFSASLEQADPE S HTP [1]
12 NPASAPDSFFSASLE S HTP [1]
15 SAPDSFFSASLEQAD S HTP [1]
11 ANPASAPDSFFSASL D HTP [1]
2 ******MSTANPASA S HTP [1]
8 MSTANPASAPDSFFS S HTP [1]
3 *****MSTANPASAP T HTP [1]
Reference
 [1]Phosphoproteomic analysis of Rhodopseudomonas palustris reveals the role of pyruvate phosphate dikinase phosphorylation in lipid production.
 Hu CW,Lin MH,Huang HC,Ku WC,Yi TH,Tsai CF,Chen YJ,Sugiyama N,Ishihama Y,Juan HF,Wu SH
 J. Proteome Res. 2012, Nov, 2;11(11):5362-75. [PMID:23030682]
Functional Description From UniProt
 FUNCTION: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Sequence Annotation From UniProt
 MOD_RES 240 240 N6-(pyridoxal phosphate)lysine (By
Key Word From UniProt
 Amino-acidbiosynthesis; Completeproteome; Cytoplasm; One-carbonmetabolism; Pyridoxalphosphate; Transferase
Protein Sequence
 MSTANPASAP DSFFSASLEQ ADPEIAAAIR GELGRQRHEV ELIASENIVS RAVLEAQGSV 60
 MTNKYAEGYP GNRYYGGCEF VDVAENLAID RAKKLFGANF ANVQPNSGSQ MNQAVFLALL 120
 QPGDTFMGLD LAAGGHLTHG APVNMSGKWF KPVHYTVRRE DQMIDMDAVA KLAEEAKPKL 180
 IIAGGSAYPR AWDFKRFREI ADSVGAYFMV DMAHFAGLVA GGVHASPVPH AHVTTTTTHK 240
 SLRGPRGGLI LTNDEALAKK FNSAIFPGLQ GGPLMHVIAA KAVAFKEALQ PDFKVYTKNV 300
 VENAKALAET LRSAGFDLVS GGTDNHLMLV DLRPKGLKGN VSEKALVRAG ITCNKNGIPF 360
 DPEKPFVTSG LRLGTPAATT RGFGVAEFQQ VGHLIAEVLN AIAQSSDGAA PLVEASVKQR 420
 VKELTDRFPI YQ 432
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004372   F:glycine hydroxymethyltransferase activity IEA:UniProtKB-HAMAP
  GO:0030170   F:pyridoxal phosphate binding IEA:UniProtKB-HAMAP
  GO:0019264   P:glycine biosynthetic process from serine IEA:UniProtKB-HAMAP
  GO:0035999   P:tetrahydrofolate interconversion IEA:UniProtKB-UniPathway
  IPR015424   PyrdxlP-dep_Trfase.
  IPR015421   PyrdxlP-dep_Trfase_major_sub1.
  IPR015422   PyrdxlP-dep_Trfase_major_sub2.
  IPR001085   Ser_HO-MeTrfase.
  IPR019798   Ser_HO-MeTrfase_PLP_BS.
  PF00464   SHMT.
  PS00096   SHMT.