※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bifunctional protein FolD
Protein Synonyms/Alias
 
Gene Name
 folD
Gene Synonyms/Alias
 TTHA1120
Created Date
 3-June-2014
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
NCBI Taxa ID
 300852
Phosphorylation
Position
Peptide
Code
Type
References
187 ATVTLAHSKTQDLPE S HTP [1]
Reference
 [1]Close proximity of phosphorylation sites to ligand in the phosphoproteome of the extreme thermophile Thermus thermophilus HB8.
 Takahata Y,Inoue M,Kim K,Iio Y,Miyamoto M,Masui R,Ishihama Y,Kuramitsu S
 Proteomics 2012, May;12(9):1414-30. [PMID:22589190]
Functional Description From UniProt
 FUNCTION: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Amino-acidbiosynthesis; Completeproteome; Histidinebiosynthesis; Hydrolase; Methioninebiosynthesis; Multifunctionalenzyme; NADP; One-carbonmetabolism; Oxidoreductase; Purinebiosynthesis; Referenceproteome
Protein Sequence
 MAAQVLSGHE AAEAVYEEIR ARLRSLSFTP SLRVIRLGED PASVAYVRLK DKRARALGYR 60
 SQVEVYPEDL PEEALLERIA ALNADEEVDG ILVQLPLPPH IRTQRVLEAI HPLKDVDGFH 120
 PLNVGRLWSG GKGLFPCTPL GVVRLLKHYG VDLRGKEVVV VGRSNIVGKP LAGLLLREDA 180
 TVTLAHSKTQ DLPEVTRRAQ VLVVAVGRPH LVRKEWVREG AIVVDVGVNR VEGRLLGDVH 240
 PEVAEVAFAL TPVPGGVGPM TVAMLMGNTL EAALLRRHGA SG 282
  GO:0004477   F:methenyltetrahydrofolate cyclohydrolase activity IEA:UniProtKB-HAMAP
  GO:0004488   F:methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA:UniProtKB-HAMAP
  GO:0009396   P:folic acid-containing compound biosynthetic process IEA:InterPro
  GO:0000105   P:histidine biosynthetic process IEA:UniProtKB-KW
  GO:0009086   P:methionine biosynthetic process IEA:UniProtKB-KW
  GO:0006164   P:purine nucleotide biosynthetic process IEA:UniProtKB-KW
  GO:0035999   P:tetrahydrofolate interconversion IEA:UniProtKB-UniPathway
  IPR016040   NAD(P)-bd_dom.
  IPR000672   THF_DH/CycHdrlase.
  IPR020630   THF_DH/CycHdrlase_cat_dom.
  IPR020867   THF_DH/CycHdrlase_CS.
  IPR020631   THF_DH/CycHdrlase_NAD-bd_dom.
  PF00763   THF_DHG_CYH.
  PF02882   THF_DHG_CYH_C.
  PS00767   THF_DHG_CYH_2.
  PR00085   THFDHDRGNASE.