※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine hydroxymethyltransferase
Protein Synonyms/Alias
 SHMT;  Serine methylase
Gene Name
 glyA
Gene Synonyms/Alias
 TTHA1524
Created Date
 3-June-2014
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
NCBI Taxa ID
 300852
Phosphorylation
Position
Peptide
Code
Type
References
51 GSVLTNKYAEGYPGA Y HTP [1]
Reference
 [1]Close proximity of phosphorylation sites to ligand in the phosphoproteome of the extreme thermophile Thermus thermophilus HB8.
 Takahata Y,Inoue M,Kim K,Iio Y,Miyamoto M,Masui R,Ishihama Y,Kuramitsu S
 Proteomics 2012, May;12(9):1414-30. [PMID:22589190]
Functional Description From UniProt
 FUNCTION: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Sequence Annotation From UniProt
 MOD_RES 226 226 N6-(pyridoxal phosphate)lysine (By
Key Word From UniProt
 3D-structure; Amino-acidbiosynthesis; Completeproteome; Cytoplasm; One-carbonmetabolism; Pyridoxalphosphate; Referenceproteome; Transferase
Protein Sequence
 MVSTLKRDEA LFELIALEEK RQREGLELIA SENFVSKQVR EAVGSVLTNK YAEGYPGARY 60
 YGGCEVIDRV ESLAIERAKA LFGAAWANVQ PHSGSQANMA VYMALMEPGD TLMGMDLAAG 120
 GHLTHGSRVN FSGKLYKVVS YGVRPDTELI DLEEVRRLAL EHRPKVIVAG ASAYPRFWDF 180
 KAFREIADEV GAYLVVDMAH FAGLVAAGLH PNPLPYAHVV TSTTHKTLRG PRGGLILSND 240
 PELGKRIDKL IFPGIQGGPL EHVIAGKAVA FFEALQPEFK EYSRLVVENA KRLAEELARR 300
 GYRIVTGGTD NHLFLVDLRP KGLTGKEAEE RLDAVGITVN KNAIPFDPKP PRVTSGIRIG 360
 TPAITTRGFT PEEMPLVAEL IDRALLEGPS EALREEVRRL ALAHPMP 407
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004372   F:glycine hydroxymethyltransferase activity IEA:UniProtKB-HAMAP
  GO:0030170   F:pyridoxal phosphate binding IEA:UniProtKB-HAMAP
  GO:0019264   P:glycine biosynthetic process from serine IEA:UniProtKB-HAMAP
  GO:0035999   P:tetrahydrofolate interconversion IEA:UniProtKB-UniPathway
  IPR015424   PyrdxlP-dep_Trfase.
  IPR015421   PyrdxlP-dep_Trfase_major_sub1.
  IPR015422   PyrdxlP-dep_Trfase_major_sub2.
  IPR001085   Ser_HO-MeTrfase.
  IPR019798   Ser_HO-MeTrfase_PLP_BS.
  PF00464   SHMT.
  PS00096   SHMT.