Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine hydroxymethyltransferase |
Protein Synonyms/Alias | SHMT; Serine methylase |
Gene Name | glyA |
Gene Synonyms/Alias | TTHA1524 |
Created Date | 3-June-2014 |
Organism | Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) |
NCBI Taxa ID | 300852 |
Phosphorylation | Position | Peptide | Code | Type | References | 51 | GSVLTNKYAEGYPGA | Y | HTP | [1] | |
Reference | [1]Close proximity of phosphorylation sites to ligand in the phosphoproteome of the extreme thermophile Thermus thermophilus HB8. Takahata Y,Inoue M,Kim K,Iio Y,Miyamoto M,Masui R,Ishihama Y,Kuramitsu S Proteomics 2012, May;12(9):1414-30. [ PMID:22589190] |
Functional Description From UniProt | FUNCTION: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) |
| MOD_RES 226 226 N6-(pyridoxal phosphate)lysine (By |
| 3D-structure; Amino-acidbiosynthesis; Completeproteome; Cytoplasm; One-carbonmetabolism; Pyridoxalphosphate; Referenceproteome; Transferase |
Protein Sequence | MVSTLKRDEA LFELIALEEK RQREGLELIA SENFVSKQVR EAVGSVLTNK YAEGYPGARY 60 YGGCEVIDRV ESLAIERAKA LFGAAWANVQ PHSGSQANMA VYMALMEPGD TLMGMDLAAG 120 GHLTHGSRVN FSGKLYKVVS YGVRPDTELI DLEEVRRLAL EHRPKVIVAG ASAYPRFWDF 180 KAFREIADEV GAYLVVDMAH FAGLVAAGLH PNPLPYAHVV TSTTHKTLRG PRGGLILSND 240 PELGKRIDKL IFPGIQGGPL EHVIAGKAVA FFEALQPEFK EYSRLVVENA KRLAEELARR 300 GYRIVTGGTD NHLFLVDLRP KGLTGKEAEE RLDAVGITVN KNAIPFDPKP PRVTSGIRIG 360 TPAITTRGFT PEEMPLVAEL IDRALLEGPS EALREEVRRL ALAHPMP 407 |
| GO:0005737 C:cytoplasm IEA:UniProtKB-SubCell GO:0004372 F:glycine hydroxymethyltransferase activity IEA:UniProtKB-HAMAP GO:0030170 F:pyridoxal phosphate binding IEA:UniProtKB-HAMAP GO:0019264 P:glycine biosynthetic process from serine IEA:UniProtKB-HAMAP GO:0035999 P:tetrahydrofolate interconversion IEA:UniProtKB-UniPathway |
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