UniProt Accession

 HIS6_SULAC;  Q4J8I9

Genbank Protein ID

 CP000077

Genbank Nucleotide ID

 AAY80891.1

Protein Name

 Imidazole glycerol phosphate synthase subunit HisF

Protein Synonyms/Alias

 IGPS subunit HisF

Gene Name

 hisF

Gene Synonyms/Alias

 Saci_1578

Created Date

 3-June-2014

Organism

 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)

NCBI Taxa ID

 330779

Phosphorylation

Reference

 [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius.
 Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV
 Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [PMID:24078887]

Functional Description From UniProt

 FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Amino-acidbiosynthesis; Completeproteome; Cytoplasm; Histidinebiosynthesis; Lyase

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0000107   F:imidazoleglycerol-phosphate synthase activity IEA:UniProtKB-HAMAP
  GO:0016829   F:lyase activity IEA:UniProtKB-KW
  GO:0000105   P:histidine biosynthetic process IEA:UniProtKB-HAMAP

  IPR013785   Aldolase_TIM.
  IPR006062   His_biosynth.
  IPR004651   HisF.
  IPR011060   RibuloseP-bd_barrel.

  PF00977   His_biosynth.