※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable tRNA sulfurtransferase
Protein Synonyms/Alias
 
Gene Name
 thiI
Gene Synonyms/Alias
 Saci_2336
Created Date
 3-June-2014
Organism
 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
NCBI Taxa ID
 330779
Phosphorylation
Position
Peptide
Code
Type
References
59 DDDYSKLSKVFGISK S HTP [1]
256 LLLKRIMYNTARVLA Y HTP [1]
65 LSKVFGISKYFEVYE S HTP [1]
Reference
 [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius.
 Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV
 Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [PMID:24078887]
Functional Description From UniProt
 FUNCTION: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 ATP-binding; Completeproteome; Cytoplasm; Nucleotide-binding; RNA-binding; Thiaminebiosynthesis; Transferase; tRNA-binding
Protein Sequence
 MPLIALTPSG EIAIKSSRSR RRFERILIKN IGKVIRVKSY KLDQGIIILN TDDDYSKLSK 60
 VFGISKYFEV YEFSFSSIQD IVNFVKDRFN QTVKGKKFAV KVKRVGNHSF NSMDVAREIG 120
 NALYPYSLGV DLENPDVKIN LILRQDYGYV YTTENDGPRG FPVGSTGKTV VLFSGGFDSP 180
 VATWMLMKRG VRPILLNFEL GGKVQRDLVL KEVDVLKQWS SNNDINVYFI NGLDVTSKLV 240
 NAEPSLRILL LKRIMYNTAR VLANKLRAYS ITTGESLSQV SSQTMINLYV TEYDIDLPVF 300
 RPLIGFDKEE IIQMSRKIGT FEYSSKLPEY CVISNKSIVK SQLDKVLEEE RKIEINYEEL 360
 IKKAELVRI 369
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0016783   F:sulfurtransferase activity IEA:UniProtKB-HAMAP
  GO:0000049   F:tRNA binding IEA:UniProtKB-HAMAP
  GO:0009228   P:thiamine biosynthetic process IEA:UniProtKB-HAMAP
  GO:0009229   P:thiamine diphosphate biosynthetic process IEA:UniProtKB-UniPathway
  GO:0034227   P:tRNA thio-modification IEA:UniProtKB-HAMAP
  IPR014729   Rossmann-like_a/b/a_fold.
  IPR020536   ThiI_C_dom.
  IPR004114   THUMP.
  IPR003720   tRNA_STrfase.
  PF02568   ThiI.
  PF02926   THUMP.
  SM00981   THUMP.
  PS51165   THUMP.