UniProt Accession

 YGHU_ECOLI;  Q46845;  Q2M9K6

Genbank Protein ID

 U28377;  U00096;  AP009048

Genbank Nucleotide ID

 AAA69156.1;  AAC76025.2;  BAE77050.1

Protein Name

 Disulfide-bond oxidoreductase YghU

Protein Synonyms/Alias

 

Gene Name

 yghU

Gene Synonyms/Alias

 b2989, JW5492

Created Date

 3-June-2014

Organism

 Escherichia coli (strain K12)

NCBI Taxa ID

 83333

Phosphorylation

Reference

 [1]Global dynamics of the Escherichia coli proteome and phosphoproteome during growth in minimal medium.
 Soares NC,Spät P,Krug K,Macek B
 J. Proteome Res. 2013, Jun, 7;12(6):2611-21. [PMID:23590516]

Functional Description From UniProt

 FUNCTION: Exhibits a robust glutathione (GSH)-dependent disulfide- bond reductase activity toward the model substrate, 2-hydroxyethyl disulfide; the actual physiological substrates are not known. Also displays a modest GSH-dependent peroxidase activity toward several organic hydroperoxides, such as cumene hydroperoxide and linoleic acid 13(S)-hydroperoxide, but does not reduce H(2)O(2) or tert- butyl hydroperoxide at appreciable rates. Exhibits little or no GSH transferase activity with most typical electrophilic substrates, and has no detectable transferase activity toward 1- chloro-2,4-dinitrobenzene (CDNB) with glutathionylspermidine (GspSH) as the nucleophilic substrate

Sequence Annotation From UniProt

 

Key Word From UniProt

 3D-structure; Completeproteome; Oxidoreductase; Peroxidase; Referenceproteome

Protein Sequence

  GO:0015036   F:disulfide oxidoreductase activity IDA:EcoCyc
  GO:0004601   F:peroxidase activity IEA:UniProtKB-KW

  IPR010987   Glutathione-S-Trfase_C-like.
  IPR004045   Glutathione_S-Trfase_N.
  IPR012336   Thioredoxin-like_fold.

  PF13409   GST_N_2.

  PS50405   GST_CTER.
  PS50404   GST_NTER.