| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Macrolide export ATP-binding/permease protein MacB 2 |
Protein Synonyms/Alias | |
Gene Name | macB2 |
Gene Synonyms/Alias | Pfl01_2215 |
Created Date | 3-June-2014 |
Organism | Pseudomonas fluorescens (strain Pf0-1) |
NCBI Taxa ID | 205922 |
Phosphorylation | Position | Peptide | Code | Type | References | | 31 | ALKNIDLTIHAGEMV | T | HTP | [1] | |
Reference | [1]Ser/Thr/Tyr phosphoproteome analysis of pathogenic and non-pathogenic Pseudomonas species. Ravichandran A,Sugiyama N,Tomita M,Swarup S,Ishihama Y Proteomics 2009, May;9(10):2764-75. [ PMID:19405024] |
Functional Description From UniProt | FUNCTION: Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides (By similarity) |
| TRANSMEM 250 270 Helical; (Potential)
TRANSMEM 276 296 Helical; (Potential)
TRANSMEM 420 440 Helical; (Potential)
TRANSMEM 524 544 Helical; (Potential)
TRANSMEM 585 605 Helical; (Potential)
TRANSMEM 614 634 Helical; (Potential) |
| Antibioticresistance; ATP-binding; Cellinnermembrane; Cellmembrane; Completeproteome; Hydrolase; Membrane; Nucleotide-binding; Transmembrane; Transmembranehelix; Transport |
Protein Sequence | MSEPLLQLTG ISRSFTAGDR EFLALKNIDL TIHAGEMVAI IGASGSGKST LMNILGCLDY 60
ATAGSYRING RETRDLDNQA LAELRRDYFG FIFQRYHLLP HLSAVHNVEM PAIYAGTPEP 120
QRHARARELL ARLGLEGHLT HRPSQLSGGQ QQRVSIARAL MNGGEVILAD EPTGALDTTS 180
GKEVMRILLE LHAAGHTVIL VTHDPKVAAN AERIIEVSDG EILSDRRNER DTAALSNEDA 240
VPKSTAARRL VASLGLFKEA FNMAWVALIS HRMRTLLTML GIVIGITSVV SISAIGEGAK 300
RYVLKDIQAI GSNTIDIYSG TSFGDSRSAA IETLVPADVT ALNQLYYVDS ATPVVGRNLL 360
LRYRNIDLDA QVNGVSDLYF QVRGIKMESG IPFSESDARR QAQVVVIDHN TRHRLFGEGV 420
DPLGQVILIG NLPCTVIGVA AENKNIFSSS KSLNVWVPYE TAAGRLLGQR YLDSISVRIK 480
DGQPSKVVED NVNKLMLQRH GTKDFFTNNL DSVMQTVQKT SRSLALLLSL IAVISLVVGG 540
IGVMNIMLVS VTERTREIGI RMAVGARQSD IRQQFLVEAV MVCLLGGAIG ISLSYAIGHL 600
FSLFIKEWEM VFSLTSVLTA VICSTLIGIV FGFVPARNAS RLDPIEALAR D 651 |
| GO:0016021 C:integral component of membrane IEA:UniProtKB-KW GO:0005886 C:plasma membrane IEA:UniProtKB-SubCell GO:0005524 F:ATP binding IEA:UniProtKB-KW GO:0016887 F:ATPase activity IEA:InterPro GO:0016820 F:hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances IEA:InterPro GO:0046677 P:response to antibiotic IEA:UniProtKB-KW |
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