※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HPr kinase/phosphorylase
Protein Synonyms/Alias
 HPrK/P
Gene Name
 hprK
Gene Synonyms/Alias
 SAK_0862
Created Date
 3-June-2014
Organism
 Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
NCBI Taxa ID
 205921
Phosphorylation
Position
Peptide
Code
Type
References
304 DRLTHLISQNEVNDD S HTP [1]
Reference
 [1]Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of group B Streptococcus.
 Burnside K,Lembo A,Harrell MI,Gurney M,Xue L,BinhTran NT,Connelly JE,Jewell KA,Schmidt BZ,de los Reyes M,Tao WA,Doran KS,Rajagopal L
 J. Biol. Chem. 2011, Dec, 23;286(51):44197-210. [PMID:22081606]
Functional Description From UniProt
 FUNCTION: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 ATP-binding; Carbohydratemetabolism; Completeproteome; Kinase; Magnesium; Metal-binding; Multifunctionalenzyme; Nucleotide-binding; Serine/threonine-proteinkinase; Transferase
Protein Sequence
 MAVTVQMLVD RLKLNVIYGD EHLLSKRITT ADISRPGLEM TGYFDYYAPE RLQLVGMKEW 60
 SYLMAMTGHN RYQVLREMFQ KETPAIVVAR DLEIPEEMYE AAKDTGIAIL QSKAPTSRLS 120
 GEVSWYLDSC LAERTSVHGV LMDIYGMGVL IQGDSGIGKS ETGLELVKRG HRLVADDRVD 180
 VYAKDEETLW GEPAEILRHL LEIRGVGIID IMSLYGASAV KDSSQVQLAI YLENFETGKV 240
 FDRLGNGNEE IELSGVKVPR IRIPVKTGRN VSVVIEAAAM NHRAKQMGFD ATQTFEDRLT 300
 HLISQNEVND D 311
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0000155   F:phosphorelay sensor kinase activity IEA:InterPro
  GO:0004674   F:protein serine/threonine kinase activity IEA:UniProtKB-KW
  GO:0004712   F:protein serine/threonine/tyrosine kinase activity IEA:UniProtKB-HAMAP
  GO:0005975   P:carbohydrate metabolic process IEA:UniProtKB-KW
  GO:0006109   P:regulation of carbohydrate metabolic process IEA:UniProtKB-HAMAP
  IPR003755   HPr(Ser)_kin/Pase.
  IPR011126   Hpr_kin/Pase_Hpr_N.
  IPR027417   P-loop_NTPase.
  IPR011104   Sig_transdc_Ser_kin/Pase_Hpr_C.
  PF07475   Hpr_kinase_C.
  PF02603   Hpr_kinase_N.