※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Peptide chain release factor 3
Protein Synonyms/Alias
 RF-3
Gene Name
 prfC
Gene Synonyms/Alias
 SAK_0897
Created Date
 3-June-2014
Organism
 Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
NCBI Taxa ID
 205921
Phosphorylation
Position
Peptide
Code
Type
References
175 WPIGMGKSFEGLYDL S HTP [1]
Reference
 [1]Serine/threonine phosphatase Stp1 mediates post-transcriptional regulation of hemolysin, autolysis, and virulence of group B Streptococcus.
 Burnside K,Lembo A,Harrell MI,Gurney M,Xue L,BinhTran NT,Connelly JE,Jewell KA,Schmidt BZ,de los Reyes M,Tao WA,Doran KS,Rajagopal L
 J. Biol. Chem. 2011, Dec, 23;286(51):44197-210. [PMID:22081606]
Functional Description From UniProt
 FUNCTION: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Cytoplasm; GTP-binding; Nucleotide-binding; Proteinbiosynthesis
Protein Sequence
 MTLQDEIKKR RTFAIISHPD AGKTTITEQL LYFGGEIREA GTVKGKKSGT FAKSDWMDIE 60
 KQRGISVTSS VMQFDYAGKR VNILDTPGHE DFSEDTYRTL MAVDAAVMVV DSAKGIEAQT 120
 KKLFEVVKHR NIPVFTFINK LDRDGREPLD LLEELEEVLG IASYPMNWPI GMGKSFEGLY 180
 DLHNKRLELY KGDERFASIE DGDQLFANNP FYEQVKEDIE LLQEAGNDFS EQAILDGDLT 240
 PVFFGSALTN FGVQTFLDTF LEFAPEPHGH KTTEGNVIDP LAKDFSGFVF KIQANMDPRH 300
 RDRIAFVRIV SGEFERGMGV NLTRTGKGAK LSNVTQFMAE SRENVTNAVA GDIIGVYDTG 360
 TYQVGDTLTV GKNKFEFEPL PTFTPELFMK VSAKNVMKQK SFHKGIEQLV QEGAIQLYKN 420
 YQTGEYMLGA VGQLQFEVFK HRMEGEYNAE VVMTPMGKKT VRWINSDDLD ERMSSSRNIL 480
 AKDRFDQPVF LFENDFALRW FADKYPDVKL EEKM 514
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005525   F:GTP binding IEA:UniProtKB-HAMAP
  GO:0003924   F:GTPase activity IEA:InterPro
  GO:0016149   F:translation release factor activity, codon specific IEA:UniProtKB-HAMAP
  GO:0006449   P:regulation of translational termination IEA:UniProtKB-HAMAP
  IPR000795   EF_GTP-bd_dom.
  IPR009022   EFG_III-V.
  IPR027417   P-loop_NTPase.
  IPR004548   PrfC.
  IPR005225   Small_GTP-bd_dom.
  IPR009000   Transl_B-barrel.
  IPR004161   Transl_elong_EFTu/EF1A_2.
  PF14492   EFG_II.
  PF00009   GTP_EFTU.
  PF03144   GTP_EFTU_D2.
  PS00301   EFACTOR_GTP.
  PR00315   ELONGATNFCT.