UniProt Accession

 TRAP_STAA8;  Q2G2F3;  Q9F949

Genbank Protein ID

 AF202641;  AJ489450;  CP000253

Genbank Nucleotide ID

 AAG32925.1;  CAD33705.1;  ABD31025.1

Protein Name

 Signal transduction protein TRAP

Protein Synonyms/Alias

 

Gene Name

 traP

Gene Synonyms/Alias

 SAOUHSC_01964

Created Date

 3-June-2014

Organism

 Staphylococcus aureus (strain NCTC 8325)

NCBI Taxa ID

 93061

Phosphorylation

Reference

 [1]Quorum sensing in Staphylococci is regulated via phosphorylation of three conserved histidine residues.
 Gov Y,Borovok I,Korem M,Singh VK,Jayaswal RK,Wilkinson BJ,Rich SM,Balaban N
 J. Biol. Chem. 2004, Apr, 9;279(15):14665-72. [PMID:14726534]

Functional Description From UniProt

 FUNCTION: Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation

Sequence Annotation From UniProt

 MOD_RES 66 66 Phosphohistidine
 MOD_RES 79 79 Phosphohistidine
 MOD_RES 154 154 Phosphohistidine

Key Word From UniProt

 3D-structure; Completeproteome; Membrane; Phosphoprotein; Referenceproteome; Virulence

Protein Sequence

  GO:0016020   C:membrane IEA:UniProtKB-SubCell
  GO:0009405   P:pathogenesis IEA:UniProtKB-KW

  IPR011008   Dimeric_a/b-barrel.