※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HTH-type transcriptional regulator MgrA
Protein Synonyms/Alias
 
Gene Name
 mgrA
Gene Synonyms/Alias
 norR, rat; OrderedLocusNames=SAOUHSC_00694
Created Date
 3-June-2014
Organism
 Staphylococcus aureus (strain NCTC 8325)
NCBI Taxa ID
 93061
Phosphorylation
Position
Peptide
Code
Type
References
66 VTELALDTGTVSPLL T LTP [1]
110 ETIRPELSNASDKVA S LTP [2]
113 RPELSNASDKVASAS S LTP [2]
Reference
 [1]Posttranslational modification influences the effects of MgrA on norA expression in Staphylococcus aureus.
 Truong-Bolduc QC,Ding Y,Hooper DC
 J. Bacteriol. 2008, Nov;190(22):7375-81. [PMID:18805983]
 [2]Phosphorylation of MgrA and its effect on expression of the NorA and NorB efflux pumps of Staphylococcus aureus.
 Truong-Bolduc QC,Hooper DC
 J. Bacteriol. 2010, May;192(10):2525-34. [PMID:20233929]
Functional Description From UniProt
 FUNCTION: Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating LytM, LytN (autolysins) and SarV (autolysis activator) and activating ArlRS, LrgAB and LytSR (autolysis inhibitors). Acts as a dual regulator for resistance to multiple drugs by inactivating NorB and tet38 and activating NorA Positively controls the expression of virulence accessory gene regulator (agr) to promote alpha-hemolysin (hla) transcription and down-regulates staphylococcal accessory regulator (sarS), leading to repression of surface protein A (spa). Binds directly to hla promoter to augment its activation. Binds to sarS promoter to down-regulate spa expression
Sequence Annotation From UniProt
 
Key Word From UniProt
 Activator; Completeproteome; Cytoplasm; Directproteinsequencing; DNA-binding; Referenceproteome; Repressor; Transcription; Transcriptionregulation; Virulence
Protein Sequence
 MSDQHNLKEQ LCFSLYNAQR QVNRYYSNKV FKKYNLTYPQ FLVLTILWDE SPVNVKKVVT 60
 ELALDTGTVS PLLKRMEQVD LIKRERSEVD QREVFIHLTD KSETIRPELS NASDKVASAS 120
 SLSQDEVKEL NRLLGKVIHA FDETKEK 147
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0003677   F:DNA binding IEA:UniProtKB-KW
  GO:0003700   F:sequence-specific DNA binding transcription factor activity IEA:InterPro
  GO:0009405   P:pathogenesis IEA:UniProtKB-KW
  GO:0006351   P:transcription, DNA-templated IEA:UniProtKB-KW
  IPR000835   HTH_MarR-typ.
  IPR023187   Tscrpt_reg_MarR-type_CS.
  IPR011991   WHTH_DNA-bd_dom.
  PF01047   MarR.
  SM00347   HTH_MARR.
  PS01117   HTH_MARR_1.
  PS50995   HTH_MARR_2.