| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Reverse gyrase |
Protein Synonyms/Alias | |
Gene Name | rgy |
Gene Synonyms/Alias | top-rg; OrderedLocusNames=Saci_0839 |
Created Date | 3-June-2014 |
Organism | Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) |
NCBI Taxa ID | 330779 |
Phosphorylation | Position | Peptide | Code | Type | References | | 827 | RWIGFKLSSILQTRF | S | HTP | [1] | | 458 | DQEVIYISRRVKDKI | S | HTP | [1] | | 993 | KDVLGDKYTNIFKPR | Y | HTP | [1] | | 832 | KLSSILQTRFWPEYC | T | HTP | [1] | | 1193 | KTKKLIPTRLGVEVN | T | HTP | [1] | |
Reference | [1]Archaeal signal transduction: impact of protein phosphatase deletions on cell size, motility, and energy metabolism in Sulfolobus acidocaldarius. Reimann J,Esser D,Orell A,Amman F,Pham TK,Noirel J,Lindås AC,Bernander R,Wright PC,Siebers B,Albers SV Mol. Cell Proteomics 2013, Dec;12(12):3908-23. [ PMID:24078887] |
Functional Description From UniProt | FUNCTION: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication |
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| ATP-binding; Completeproteome; Directproteinsequencing; DNA-binding; Helicase; Hydrolase; Isomerase; Magnesium; Metal-binding; Nucleotide-binding; Topoisomerase; Zinc; Zinc-finger |
Protein Sequence | MQSLSDIPPS IYLFSCPNCG RSISTYRLLL GSVCNICLEE DKEYKNIGDL IKDIEKQGNL 60
IKLKDIQRVL DDYESFVSVF RRLLGFPPFG PQKSWIYRLL SGESFAIIAP PGLGKTTFGL 120
ISSIYLYLRG KKSILVFPTK SLVRQAIDKL SSYIQNLAEI KENPPKVIYY YSGMSASERK 180
EADEGLQSKT FDIFISTNRF LIDNIDQISS TSYQFLFVDD VDTALKSSKS AQAILKLLGF 240
TPSDQDKIKE SLKKYRENTQ KNEQNEYIFE EIDKIRKDRL ASKTVIFSSA TLNRSNPILT 300
SLVGFKPGSS VIYIRKVYDM YVKQPDKEQE TFNLIKSLLH RLGDGGLIFV PVDKKQEYIK 360
RLQSELSNEF NVAAITSTSA TKIDDFANGE IDVLIGSATH YGILVRGLDL PWRVKYSIFV 420
GIPKFKFRLG EKVNLLTLSR LLSLIALITK DQEVIYISRR VKDKIRRLSP AALTMLSVQA 480
KEGKLEDSIL LKAYDLLNKY LSNQNVLKRI SEIGDFVLSP DNDILIPDYL TYVQASGRTS 540
RIYAGDVTTG LSILLVDDFN LFRLLNKKLQ YILDDIQWRE LDVEKWTAGD VEIKNLISKI 600
NEERNEISKL KNEGNVAPAL QKVKTVLLVV ESPNKAKTIS SFFSRPSIRQ IGNMRVYETV 660
LGDKVLMVTA SGGHVYDLTT QDMGIYGVDI MKQNSSLVFI PIYNSIKKCE NNHQFTDFFE 720
SNKCPRCMTT KVRYDSLKSI NVLRNLAVEA DEVLIGTDPD TEGEKIAWDL YLALRPYNSN 780
IRRAEFHEVT RKAILQAINQ PREFNVNLVK SQLVRRIEDR WIGFKLSSIL QTRFWPEYCK 840
SLSSNKQLNC NENKNLSAGR VQTPVLSWIV DRYTEYQRNK SRVYYGKIDQ LQDIVIYVPK 900
QDGVRKNSKI VVVFNEINQL EEEFGPLPPY TTDTLLSDSN NFFGLSAPET MRIAQDLFEL 960
GLITYHRTDS NRISNTGISV AENYLKDVLG DKYTNIFKPR SWGDGGAHEG IRPTKPIDVE 1020
QLRLLIEEGE LELAKRLTNN HFKVYDIIFR RFISSQIIPL KVRKEIVKIE LYGENKKEKI 1080
NSNQNIIEVI TGITLPGIDT EISKFAYVPV RNVSRSVAER LKELGRSIPT DFSIEISNSF 1140
IKSTVNLYTQ ADLVMEMKNK KIGRPSTYAT IIGTILRRGY VLESLKTKKL IPTRLGVEVN 1200
KYLNENYGRF VSEDRTRKLL QLMDMVEAGQ EKYEEVLKQV YEEINEIR 1248 |
| GO:0005694 C:chromosome IEA:InterPro GO:0005524 F:ATP binding IEA:UniProtKB-HAMAP GO:0008026 F:ATP-dependent helicase activity IEA:InterPro GO:0003677 F:DNA binding IEA:UniProtKB-HAMAP GO:0003917 F:DNA topoisomerase type I activity IEA:InterPro GO:0003918 F:DNA topoisomerase type II (ATP-hydrolyzing) activity IEA:UniProtKB-HAMAP GO:0000287 F:magnesium ion binding IEA:UniProtKB-HAMAP GO:0008270 F:zinc ion binding IEA:UniProtKB-HAMAP GO:0006265 P:DNA topological change IEA:UniProtKB-HAMAP GO:0006268 P:DNA unwinding involved in DNA replication IEA:UniProtKB-HAMAP |
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