UniProt Accession

 GRPE_STRCO;  Q05562

Genbank Protein ID

 X77458;  L46700;  AL939117

Genbank Nucleotide ID

 CAA54607.1;  AAB29452.1;  CAB91161.1

Protein Name

 Protein GrpE

Protein Synonyms/Alias

 

Gene Name

 grpE

Gene Synonyms/Alias

 SCO3670; ORFNames=SCH44.10c

Created Date

 3-June-2014

Organism

 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

NCBI Taxa ID

 100226

Phosphorylation

Reference

 [1]Phosphoproteome analysis of Streptomyces development reveals extensive protein phosphorylation accompanying bacterial differentiation.
 Manteca A,Ye J,Sánchez J,Jensen ON
 J. Proteome Res. 2011, Dec, 2;10(12):5481-92. [PMID:21999169]

Functional Description From UniProt

 FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Chaperone; Completeproteome; Cytoplasm; Referenceproteome; Stressresponse

Protein Sequence

  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0000774   F:adenyl-nucleotide exchange factor activity IEA:InterPro
  GO:0006457   P:protein folding IEA:InterPro
  GO:0006950   P:response to stress IEA:UniProtKB-KW

  IPR000740   GrpE.
  IPR013805   GrpE_coiled_coil.
  IPR009012   GrpE_head.

  PF01025   GrpE.

  PS01071   GRPE.

  PR00773   GRPEPROTEIN.