※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Adenylosuccinate synthetase
Protein Synonyms/Alias
 AMPSase;  AdSS
Gene Name
 purA
Gene Synonyms/Alias
 SPD_0024
Created Date
 3-June-2014
Organism
 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
NCBI Taxa ID
 373153
Phosphorylation
Position
Peptide
Code
Type
References
410 LVGVRISTFSVGPGR T HTP [1]
412 GVRISTFSVGPGREQ S HTP [1]
42 GGDNAGHTIVIDGKK T HTP [1]
33 NAEVIARYQGGDNAG Y HTP [1]
401 RNYVRRVSELVGVRI S HTP [1]
128 GDNKIGTTIKGIGPA T HTP [1]
Reference
 [1]Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae.
 Sun X,Ge F,Xiao CL,Yin XF,Ge R,Zhang LH,He QY
 J. Proteome Res. 2010, Jan;9(1):275-82. [PMID:19894762]
Functional Description From UniProt
 FUNCTION: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Cytoplasm; GTP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding; Purinebiosynthesis
Protein Sequence
 MTSVVVVGTQ WGDEGKGKIT DFLSANAEVI ARYQGGDNAG HTIVIDGKKF KLHLIPSGIF 60
 FPEKISVIGN GMVVNPKSLV KELSYLHEEG VTTDNLRISD RAHVILPYHI ELDRLQEEAK 120
 GDNKIGTTIK GIGPAYMDKA ARVGIRIADL LDKDIFRERL ERNLAEKNRL FEKLYDSKAI 180
 VFDDIFEEYY EYGQQIKKYV IDTSVILNDA LDNGKRVLFE GAQGVMLDID QGTYPFVTSS 240
 NPVAGGVTIG SGVGPSKIDK VVGVCKAYTS RVGDGPFPTE LFDEVGERIR EVGHEYGTTT 300
 GRPRRVGWFD SVVMRHSRRV SGITNLSLNS IDVLSGLDTV KICVAYDLDG QRIDYYPASL 360
 EQLKRCKPIY EELPGWSEDI TGVRNLEDLP ENARNYVRRV SELVGVRIST FSVGPGREQT 420
 NILESVWS 428
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004019   F:adenylosuccinate synthase activity IEA:UniProtKB-HAMAP
  GO:0005525   F:GTP binding IEA:UniProtKB-HAMAP
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0044208   P:'de novo' AMP biosynthetic process IEA:UniProtKB-UniPathway
  IPR018220   Adenylosuccinate_synthase_AS.
  IPR001114   Adenylosuccinate_synthetase.
  IPR027417   P-loop_NTPase.
  PF00709   Adenylsucc_synt.
  SM00788   Adenylsucc_synt.
  PS01266   ADENYLOSUCCIN_SYN_1.
  PS00513   ADENYLOSUCCIN_SYN_2.