※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 S-adenosylmethionine synthase
Protein Synonyms/Alias
 AdoMet synthase
Gene Name
 metK
Gene Synonyms/Alias
 SPD_0664
Created Date
 3-June-2014
Organism
 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
NCBI Taxa ID
 373153
Phosphorylation
Position
Peptide
Code
Type
References
286 DATKVDRSASYAARY S HTP [1]
Reference
 [1]Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae.
 Sun X,Ge F,Xiao CL,Yin XF,Ge R,Zhang LH,He QY
 J. Proteome Res. 2010, Jan;9(1):275-82. [PMID:19894762]
Functional Description From UniProt
 FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 ATP-binding; Cobalt; Completeproteome; Cytoplasm; Magnesium; Metal-binding; Nucleotide-binding; One-carbonmetabolism; Potassium; Transferase
Protein Sequence
 MSERKLFTSE SVSEGHPDKI ADQISDAILD AILAKDPEAH VAAETAVYTG SVHVFGEIST 60
 NAYVDINRVV RDTIAEIGYT NTEYGFSAET VGVHPSLVEQ SPDIAQGVNE ALEVRGNADQ 120
 DPLDLIGAGD QGLMFGFAVD ETEELMPLPI ALSHKLVRRL AELRKSGEIS YLRPDAKSQV 180
 TVEYDENDRP VRVDTVVIST QHDPEATNEQ IHQDVIDKVI KEVIPSSYLD DKTKFFINPT 240
 GRFVIGGPQG DSGLTGRKII VDTYGGYSRH GGGAFSGKDA TKVDRSASYA ARYIAKNIVA 300
 AGLAKKAEVQ LAYAIGVAQP VSVRIDTFGT GTVAESQLEK AARQIFDLRP AGIIQMLDLK 360
 RPIYRQTSAY GHMGRTDIDL PWERLDKVDA LKEAVK 396
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0000287   F:magnesium ion binding IEA:UniProtKB-HAMAP
  GO:0004478   F:methionine adenosyltransferase activity IEA:UniProtKB-HAMAP
  GO:0006730   P:one-carbon metabolic process IEA:UniProtKB-HAMAP
  GO:0006556   P:S-adenosylmethionine biosynthetic process IEA:UniProtKB-UniPathway
  IPR022631   ADOMET_SYNTHASE_CS.
  IPR022630   S-AdoMet_synt_C.
  IPR022629   S-AdoMet_synt_central.
  IPR022628   S-AdoMet_synt_N.
  IPR002133   S-AdoMet_synthetase.
  IPR022636   S-AdoMet_synthetase_sfam.
  PF02773   S-AdoMet_synt_C.
  PF02772   S-AdoMet_synt_M.
  PF00438   S-AdoMet_synt_N.
  PS00376   ADOMET_SYNTHASE_1.
  PS00377   ADOMET_SYNTHASE_2.