※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alanine--tRNA ligase
Protein Synonyms/Alias
 AlaRS
Gene Name
 alaS
Gene Synonyms/Alias
 SPD_1216
Created Date
 3-June-2014
Organism
 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
NCBI Taxa ID
 373153
Phosphorylation
Position
Peptide
Code
Type
References
780 NGHRYIASQVSVSDA S HTP [1]
783 RYIASQVSVSDAGAL S HTP [1]
785 IASQVSVSDAGALRT S HTP [1]
Reference
 [1]Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae.
 Sun X,Ge F,Xiao CL,Yin XF,Ge R,Zhang LH,He QY
 J. Proteome Res. 2010, Jan;9(1):275-82. [PMID:19894762]
Functional Description From UniProt
 FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; RNA-binding; tRNA-binding; Zinc
Protein Sequence
 MKQLSSAQVR QMWLDFWATK GHSVEPSVSL VPVNDPTLLW INSGVATLKK YFDGTIIPEN 60
 PRITNAQKAI RTNDIENVGK TARHHTMFEM LGNFSIGDYF RDEAITWAYE LLTSPEWFDF 120
 PAEKLYMTYY PDDKDSYNRW IEVGVDPSHL IPIEDNFWEI GAGPSGPDTE IFFDRGEAFD 180
 PENIGLRLLA EDIENDRYIE IWNIVLSQFN ADPAVPRSEY KELPHKNIDT GAGLERLVAV 240
 IQGAKTNFET DLFMPIIREV EKLSGKVYDQ DGDNMSFKVI ADHIRSLSFA IGDGALPGNE 300
 GRGYVLRRLL RRASMHGQKL GINEPFLYKL VPTVGKIMES YYPEVLEKRD FIEKIVKSEE 360
 ESFARTLHSG QHFAQGIVAD LKEKGQSVIA GQDVFKLYDT YGFPVELTEE IAEEAGMTVD 420
 REGFEAAMKE QQERARASAV KGGSMGMQNE TLQNITVESV FNYNTSQLSS KLVAIVADNA 480
 EVGAVSEGTA SLIFAETSFY AEMGGQVADY GQILDESGKI VATVTNVQKA PNGQALHTVE 540
 VLAPLALNQE YTLAIDSNRR HRVMKNHTAT HLLHAALHNI LGNHATQAGS LNEVEFLRFD 600
 FTHFQAVTAE ELRAIEQQVN EKIWEALEVK TVETDIDTAK EMGAMALFGE KYGKEVRVVT 660
 IGDYSIELCG GTHVDNTSEI GLFKIVKEEG IGSGTRRILA VTGKEAFEAY REQEDALKAI 720
 AATLKAPQVK EVPHKVEGLQ EQLRQLQKEN AELKEKAAAA AAGDIFKDVK EVNGHRYIAS 780
 QVSVSDAGAL RTFADNWKQK DYSDLLVLVA AIGDKVNVLV ASKTKDLHAG NLVKELAPII 840
 DGRGGGKPDM AMAGGSNQPK IQELLDAVAG KL 872
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004813   F:alanine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0000049   F:tRNA binding IEA:UniProtKB-KW
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006419   P:alanyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR002318   Ala-tRNA-lgiase_IIc.
  IPR018162   Ala-tRNA-ligase_IIc_anticod-bd.
  IPR018165   Ala-tRNA-synth_IIc_core.
  IPR018164   Ala-tRNA-synth_IIc_N.
  IPR023033   Ala_tRNA_ligase_euk/bac.
  IPR003156   Pesterase_DHHA1.
  IPR018163   Thr/Ala-tRNA-synth_IIc_edit.
  IPR009000   Transl_B-barrel.
  IPR012947   tRNA_SAD.
  PF02272   DHHA1.
  PF01411   tRNA-synt_2c.
  PF07973   tRNA_SAD.
  SM00863   tRNA_SAD.
  PS50860   AA_TRNA_LIGASE_II_ALA.
  PR00980   TRNASYNTHALA.