※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isoleucine--tRNA ligase
Protein Synonyms/Alias
 IleRS
Gene Name
 ileS
Gene Synonyms/Alias
 SPD_1472
Created Date
 3-June-2014
Organism
 Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
NCBI Taxa ID
 373153
Phosphorylation
Position
Peptide
Code
Type
References
6 **MKLKDTLNLGKTE T HTP [1]
22 PMRAGLPTKEPVWQK T HTP [1]
Reference
 [1]Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae.
 Sun X,Ge F,Xiao CL,Yin XF,Ge R,Zhang LH,He QY
 J. Proteome Res. 2010, Jan;9(1):275-82. [PMID:19894762]
Functional Description From UniProt
 FUNCTION: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; Zinc
Protein Sequence
 MKLKDTLNLG KTEFPMRAGL PTKEPVWQKE WEYAKLYQRR QELNQGKPHF TLHDGPPYAN 60
 GNIHVGHAMN KISKDIIVRS KSMSGFYAPF IPGWDTHGLP IEQVLSKQGV KRKEMDLVEY 120
 LKLCREYALS QVDKQREDFK RLGVSGDWEN PYVTLTPDYE AAQIRVFGEM ANKGYIYRGA 180
 KPVYWSWSSE SALAEAEIEY HDLVSTSLYY ANKVKDGKGV LDTDTYIVVW TTTPFTITAS 240
 RGLTVGADID YVLVQPAGEA RKFVVAAELL TSLSEKFGWA DVQVLETYRG QELNHIVTEH 300
 PWDTAVEELV ILGDHVTTDS GTGIVHTAPG FGEDDYNVGI ANNLEVAVTV DERGIMMKNA 360
 GPEFEGQFYE KVVPTVIEKL GNLLLAQEEI SHSYPFDWRT KKPIIWRAVP QWFASVSKFR 420
 QEILDEIEKV KFHSEWGKVR LYNMIRDRGD WVISRQRAWG VPLPIFYAED GTAIMVAETI 480
 EHVAQLFEEH GSSIWWERDA KDLLPEGFTH PGSPNGEFKK ETDIMDVWFD SGSSWNGVVV 540
 NRPELTYPAD LYLEGSDQYR GWFNSSLITS VANHGVAPYK QILSQGFALD GKGEKMSKSL 600
 GNTIAPSDVE KQFGAEILRL WVTSVDSSND VRISMDILSQ VSETYRKIRN TLRFLIANTS 660
 DFNPAQDTVA YDELRSVDKY MTIRFNQLVK TIRDAYADFE FLTIYKALVN FINVDLSAFY 720
 LDFAKDVVYI EGAKSLERRQ MQTVFYDILV KITKLLTPIL PHTAEEIWSY LEFETEDFVQ 780
 LSELPEVQTF ANQEEILDTW AAFMDFRGQA QKALEEARNA KVIGKSLEAH LTVYPNEVVK 840
 TLLEAVNSNV AQLLIVSELT IAEGPAPEAA LSFEDVAFTV ERATGEVCDR CRRIDPTTAE 900
 RSYQAVICDH CASIVEENFA EAVAEGFEEK 930
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0002161   F:aminoacyl-tRNA editing activity IEA:InterPro
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0004822   F:isoleucine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0008270   F:zinc ion binding IEA:UniProtKB-HAMAP
  GO:0006428   P:isoleucyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR001412   aa-tRNA-synth_I_CS.
  IPR002300   aa-tRNA-synth_Ia.
  IPR002301   Ile-tRNA-ligase.
  IPR023585   Ile-tRNA-ligase_type1.
  IPR014729   Rossmann-like_a/b/a_fold.
  IPR009080   tRNAsynth_1a_anticodon-bd.
  IPR013155   V/L/I-tRNA-synth_anticodon-bd.
  IPR009008   Val/Leu/Ile-tRNA-synth_edit.
  PF08264   Anticodon_1.
  PF00133   tRNA-synt_1.
  PS00178   AA_TRNA_LIGASE_I.
  PR00984   TRNASYNTHILE.