| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chaperone protein ClpB |
Protein Synonyms/Alias | |
Gene Name | clpB |
Gene Synonyms/Alias | MT0397 |
Created Date | 3-June-2014 |
Organism | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
NCBI Taxa ID | 83331 |
Phosphorylation | Position | Peptide | Code | Type | References | | 79 | PQATGASTQPQLSRE | T | HTP | [1] | |
Reference | [1]Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. Prisic S,Dankwa S,Schwartz D,Chou MF,Locasale JW,Kang CM,Bemis G,Church GM,Steen H,Husson RN Proc. Natl. Acad. Sci. U.S.A. 2010, Apr, 20;107(16):7521-6. [ PMID:20368441] |
Functional Description From UniProt | FUNCTION: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity) |
| COILED 392 524 By similarity |
| ATP-binding; Chaperone; Coiledcoil; Completeproteome; Cytoplasm; Nucleotide-binding; Repeat; Stressresponse |
Protein Sequence | MDSFNPTTKT QAALTAALQA ASTAGNPEIR PAHLLMALLT QNDGIAAPLL EAVGVEPATV 60
RAETQRLLDR LPQATGASTQ PQLSRESLAA ITTAQQLATE LDDEYVSTEH VMVGLATGDS 120
DVAKLLTGHG ASPQALREAF VKVRGSARVT SPEPEATYQA LQKYSTDLTA RAREGKLDPV 180
IGRDNEIRRV VQVLSRRTKN NPVLIGEPGV GKTAIVEGLA QRIVAGDVPE SLRDKTIVAL 240
DLGSMVAGSK YRGEFEERLK AVLDDIKNSA GQIITFIDEL HTIVGAGATG EGAMDAGNMI 300
KPMLARGELR LVGATTLDEY RKHIEKDAAL ERRFQQVYVG EPSVEDTIGI LRGLKDRYEV 360
HHGVRITDSA LVAAATLSDR YITARFLPDK AIDLVDEAAS RLRMEIDSRP VEIDEVERLV 420
RRLEIEEMAL SKEEDEASAE RLAKLRSELA DQKEKLAELT TRWQNEKNAI EIVRDLKEQL 480
EALRGESERA ERDGDLAKAA ELRYGRIPEV EKKLDAALPQ AQAREQVMLK EEVGPDDIAD 540
VVSAWTGIPA GRLLEGETAK LLRMEDELGK RVIGQKAAVT AVSDAVRRSR AGVSDPNRPT 600
GAFMFLGPTG VGKTELAKAL ADFLFDDERA MVRIDMSEYG EKHTVARLIG APPGYVGYEA 660
GGQLTEAVRR RPYTVVLFDE IEKAHPDVFD VLLQVLDEGR LTDGHGRTVD FRNTILILTS 720
NLGSGGSAEQ VLAAVRATFK PEFINRLDDV LIFEGLNPEE LVRIVDIQLA QLGKRLAQRR 780
LQLQVSLPAK RWLAQRGFDP VYGARPLRRL VQQAIGDQLA KMLLAGQVHD GDTVPVNVSP 840
DADSLILG 848 |
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