UniProt Accession

 DNAJ1_MYCTO;  P9WNV8;  A7BJ09;  F2GN42;  O08380;  P07881;  P0A548

Genbank Protein ID

 AE000516

Genbank Nucleotide ID

 AAK44589.1

Protein Name

 Chaperone protein DnaJ 1

Protein Synonyms/Alias

 

Gene Name

 dnaJ1

Gene Synonyms/Alias

 MT0367

Created Date

 3-June-2014

Organism

 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

NCBI Taxa ID

 83331

Phosphorylation

Reference

 [1]Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.
 Prisic S,Dankwa S,Schwartz D,Chou MF,Locasale JW,Kang CM,Bemis G,Church GM,Steen H,Husson RN
 Proc. Natl. Acad. Sci. U.S.A. 2010, Apr, 20;107(16):7521-6. [PMID:20368441]

Functional Description From UniProt

 FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Chaperone; Completeproteome; Cytoplasm; DNAreplication; Metal-binding; Repeat; Stressresponse; Zinc; Zinc-finger

Protein Sequence

  IPR012724   DnaJ.
  IPR002939   DnaJ_C.
  IPR001623   DnaJ_domain.
  IPR018253   DnaJ_domain_CS.
  IPR008971   HSP40/DnaJ_pept-bd.
  IPR001305   HSP_DnaJ_Cys-rich_dom.

  PF01556   CTDII.
  PF00226   DnaJ.
  PF00684   DnaJ_CXXCXGXG.

  SM00271   DnaJ.

  PS00636   DNAJ_1.
  PS50076   DNAJ_2.
  PS51188   ZF_CR.

  PR00625   JDOMAIN.