UniProt Accession

 FABH_MYCTO;  P9WNG2;  L0T424;  O06399;  P0A574

Genbank Protein ID

 AE000516

Genbank Nucleotide ID

 AAK44780.1

Protein Name

 3-oxoacyl-[acyl-carrier-protein] synthase 3

Protein Synonyms/Alias

 KAS III

Gene Name

 fabH

Gene Synonyms/Alias

 MT0557

Created Date

 3-June-2014

Organism

 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

NCBI Taxa ID

 83331

Phosphorylation

Reference

 [1]The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
 Veyron-Churlet R,Molle V,Taylor RC,Brown AK,Besra GS,Zanella-Cléon I,Fütterer K,Kremer L
 J. Biol. Chem. 2009, Mar, 6;284(10):6414-24. [PMID:19074144]

Functional Description From UniProt

 FUNCTION: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for long chain acyl-CoA such as myristoyl-CoA. Does not use acyl-CoA as primer. Its substrate specificity determines the biosynthesis of mycolic acid fatty acid chain, which is characteristic of mycobacterial cell wall (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Acyltransferase; Completeproteome; Cytoplasm; Fattyacidbiosynthesis; Fattyacidmetabolism; Lipidbiosynthesis; Lipidmetabolism; Multifunctionalenzyme; Transferase

Protein Sequence

  IPR013751   ACP_syn_III.
  IPR013747   ACP_syn_III_C.
  IPR004655   FabH_synth.
  IPR016039   Thiolase-like.
  IPR016038   Thiolase-like_subgr.

  PF08545   ACP_syn_III.
  PF08541   ACP_syn_III_C.