UniProt Accession

 GRPE_MYCTO;  P9WMT4;  L0T3E5;  O08379;  P32724

Genbank Protein ID

 AE000516

Genbank Nucleotide ID

 AAK44588.1

Protein Name

 Protein GrpE

Protein Synonyms/Alias

 

Gene Name

 grpE

Gene Synonyms/Alias

 MT0366

Created Date

 3-June-2014

Organism

 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

NCBI Taxa ID

 83331

Phosphorylation

Reference

 [1]Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.
 Prisic S,Dankwa S,Schwartz D,Chou MF,Locasale JW,Kang CM,Bemis G,Church GM,Steen H,Husson RN
 Proc. Natl. Acad. Sci. U.S.A. 2010, Apr, 20;107(16):7521-6. [PMID:20368441]

Functional Description From UniProt

 FUNCTION: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity)

Sequence Annotation From UniProt

 

Key Word From UniProt

 Chaperone; Completeproteome; Cytoplasm; Stressresponse.

Protein Sequence

  IPR000740   GrpE.
  IPR013805   GrpE_coiled_coil.
  IPR009012   GrpE_head.

  PF01025   GrpE.

  PS01071   GRPE.

  PR00773   GRPEPROTEIN.