※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase PknD
Protein Synonyms/Alias
 
Gene Name
 pknD
Gene Synonyms/Alias
 MT0958
Created Date
 3-June-2014
Organism
 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
NCBI Taxa ID
 83331
Phosphorylation
Position
Peptide
Code
Type
References
135 AAHANGVTHRDVKPE T HTP [1]
171 SDPGLTQTGTAVGTY T HTP [1]
169 AASDPGLTQTGTAVG T HTP [1]
173 PGLTQTGTAVGTYNY T HTP [1]
209 CVLGECLTGAPPYRA T HTP [1]
303 LLATPADTGLSQSES T HTP [2]
306 TPADTGLSQSESGIA S HTP [2]
317 SGIAGAGTGPPTPGA T HTP [2]
334 WSPGDSATVAGPLAA T HTP [2]
624 VVKLLAGSTTSTVLP S HTP [2]
Reference
 [1]Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.
 Durán R,Villarino A,Bellinzoni M,Wehenkel A,Fernandez P,Boitel B,Cole ST,Alzari PM,Cerveñansky C
 Biochem. Biophys. Res. Commun. 2005, Aug, 5;333(3):858-67. [PMID:15967413]
 [2]Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.
 Prisic S,Dankwa S,Schwartz D,Chou MF,Locasale JW,Kang CM,Bemis G,Church GM,Steen H,Husson RN
 Proc. Natl. Acad. Sci. U.S.A. 2010, Apr, 20;107(16):7521-6. [PMID:20368441]
Functional Description From UniProt
 FUNCTION: Key microbial factor required for central nervous system tuberculosis. Required for invasion of host brain endothelia, but not macrophages, lung epithelia or other endothelia
Sequence Annotation From UniProt
 TRANSMEM 382 402 Helical; (Potential)
 MOD_RES 135 135 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 169 169 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 171 171 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 173 173 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 209 209 Phosphothreonine; by autocatalysis (By similarity)
Key Word From UniProt
 ATP-binding; Cellmembrane; Completeproteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Repeat; Serine/threonine-proteinkinase; Transferase; Transmembrane; Transmembranehelix; Virulence
Protein Sequence
 MSDAVPQVGS QFGPYQLLRL LGRGGMGEVY EAEDTRKHRV VALKLISPQY SDNAVFRARM 60
 QREADTAGRL TEPHIVPIHD YGEINGQFFV EMRMIDGTSL RALLKQYGPL TPARAVAIVR 120
 QIAAALDAAH ANGVTHRDVK PENILVTASD FAYLVDFGIA RAASDPGLTQ TGTAVGTYNY 180
 MAPERFTGDE VTYRADIYAL ACVLGECLTG APPYRADSVE RLIAAHLMDP APQPSQLRPG 240
 RVPPALDQVI AKGMAKNPAE RFMSAGDLAI AAHDALTTSE QHQATTILRR GDNATLLATP 300
 ADTGLSQSES GIAGAGTGPP TPGAARWSPG DSATVAGPLA ADSRGGNWPS QTGHSPAVPN 360
 ALQASLGHAV PPAGNKRKVW AVVGAAAIVL VAIVAAAGYL VLRPSWSPTQ ASGQTVLPFT 420
 GIDFRLSPSG VAVDSAGNVY VTSEGMYGRV VKLATGSTGT TVLPFNGLYQ PQGLAVDGAG 480
 TVYVTDFNNR VVTLAAGSNN QTVLPFDGLN YPEGLAVDTQ GAVYVADRGN NRVVKLAAGS 540
 KTQTVLPFTG LNDPDGVAVD NSGNVYVTDT DNNRVVKLEA ESNNQVVLPF TDITAPWGIA 600
 VDEAGTVYVT EHNTNQVVKL LAGSTTSTVL PFTGLNTPLA VAVDSDRTVY VADRGNDRVV 660
 KLTS 664
  IPR011042   6-blade_b-propeller_TolB-like.
  IPR011009   Kinase-like_dom.
  IPR001258   NHL_repeat.
  IPR013017   NHL_repeat_subgr.
  IPR000719   Prot_kinase_dom.
  IPR017441   Protein_kinase_ATP_BS.
  IPR008271   Ser/Thr_kinase_AS.
  PF01436   NHL.
  PF00069   Pkinase.
  PS51125   NHL.
  PS00107   PROTEIN_KINASE_ATP.
  PS50011   PROTEIN_KINASE_DOM.
  PS00108   PROTEIN_KINASE_ST.