※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase PknE
Protein Synonyms/Alias
 
Gene Name
 pknE
Gene Synonyms/Alias
 MT1785
Created Date
 3-June-2014
Organism
 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
NCBI Taxa ID
 83331
Phosphorylation
Position
Peptide
Code
Type
References
59 SSDPVFRTRMQREAR T HTP [1]
50 ALKLMSETLSSDPVF T HTP [1]
7 *MDGTAESREGTQFG S HTP [1]
170 ATTDEKLTQLGNTVG T HTP [1]
175 KLTQLGNTVGTLYYM T HTP [1]
178 QLGNTVGTLYYMAPE T HTP [1]
11 TAESREGTQFGPYRL T HTP [1]
Reference
 [1]Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.
 Durán R,Villarino A,Bellinzoni M,Wehenkel A,Fernandez P,Boitel B,Cole ST,Alzari PM,Cerveñansky C
 Biochem. Biophys. Res. Commun. 2005, Aug, 5;333(3):858-67. [PMID:15967413]
Functional Description From UniProt
 FUNCTION: Important for survival of the bacterium in the host during infection. Promotes the survival of infected macrophages by activating multiple signaling responses and suppressing apoptosis of macrophages during nitrate stress. May contribute to the adaptation of M.tuberculosis during stress conditions by maintaining the cellular integrity (By similarity)
Sequence Annotation From UniProt
 TRANSMEM 338 358 Helical; (Potential)
 MOD_RES 7 7 Phosphoserine; by autocatalysis (By similarity)
 MOD_RES 11 11 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 50 50 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 59 59 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 170 170 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 175 175 Phosphothreonine; by autocatalysis (By similarity)
 MOD_RES 178 178 Phosphothreonine; by autocatalysis (By similarity)
Key Word From UniProt
 ATP-binding; Cellmembrane; Completeproteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Serine/threonine-proteinkinase; Stressresponse; Transferase; Transmembrane; Transmembranehelix; Virulence
Protein Sequence
 MDGTAESREG TQFGPYRLRR LVGRGGMGDV YEAEDTVRER IVALKLMSET LSSDPVFRTR 60
 MQREARTAGR LQEPHVVPIH DFGEIDGQLY VDMRLINGVD LAAMLRRQGP LAPPRAVAIV 120
 RQIGSALDAA HAAGATHRDV KPENILVSAD DFAYLVDFGI ASATTDEKLT QLGNTVGTLY 180
 YMAPERFSES HATYRADIYA LTCVLYECLT GSPPYQGDQL SVMGAHINQA IPRPSTVRPG 240
 IPVAFDAVIA RGMAKNPEDR YVTCGDLSAA AHAALATADQ DRATDILRRS QVAKLPVPST 300
 HPVSPGTRWP QPTPWAGGAP PWGPPSSPLP RSARQPWLWV GVAVAVVVAL AGGLGIALAH 360
 PWRSSGPRTS APPPPPPADA VELRVLNDGV FVGSSVAPTT IDIFNEPICP PCGSFIRSYA 420
 SDIDTAVADK QLAVRYHLLN FLDDQSHSKN YSTRAVAASY CVAGQNDPKL YASFYSALFG 480
 SDFQPQENAA SDRTDAELAH LAQTVGAEPT AISCIKSGAD LGTAQTKATN ASETLAGFNA 540
 SGTPFVWDGS MVVNYQDPSW LARLIG 566
  IPR011009   Kinase-like_dom.
  IPR000719   Prot_kinase_dom.
  IPR017441   Protein_kinase_ATP_BS.
  IPR012336   Thioredoxin-like_fold.
  PF00069   Pkinase.
  PF13462   Thioredoxin_4.
  PS00107   PROTEIN_KINASE_ATP.
  PS50011   PROTEIN_KINASE_DOM.