| Tag | Content |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase PknG |
Protein Synonyms/Alias | |
Gene Name | pknG |
Gene Synonyms/Alias | MT0423 |
Created Date | 3-June-2014 |
Organism | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
NCBI Taxa ID | 83331 |
Phosphorylation | Position | Peptide | Code | Type | References | | 23 | PADAQTATSATVRPL | T | LTP | [1] | | 32 | ATVRPLSTQAVFRPD | T | LTP | [1] | |
Reference | [1]Regulation of glutamate metabolism by protein kinases in mycobacteria. O'Hare HM,Durán R,Cerveñansky C,Bellinzoni M,Wehenkel AM,Pritsch O,Obal G,Baumgartner J,Vialaret J,Johnsson K,Alzari PM Mol. Microbiol. 2008, Dec;70(6):1408-23. [ PMID:19019160] |
Functional Description From UniProt | FUNCTION: Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance (By similarity) |
| MOD_RES 63 63 Phosphothreonine (By similarity) |
| Antibioticresistance; ATP-binding; Cellmembrane; Completeproteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Serine/threonine-proteinkinase; TPRrepeat; Transferase; Virulence |
Protein Sequence | MAKASETERS GPGTQPADAQ TATSATVRPL STQAVFRPDF GDEDNFPHPT LGPDTEPQDR 60
MATTSRVRPP VRRLGGGLVE IPRAPDIDPL EALMTNPVVP ESKRFCWNCG RPVGRSDSET 120
KGASEGWCPY CGSPYSFLPQ LNPGDIVAGQ YEVKGCIAHG GLGWIYLALD RNVNGRPVVL 180
KGLVHSGDAE AQAMAMAERQ FLAEVVHPSI VQIFNFVEHT DRHGDPVGYI VMEYVGGQSL 240
KRSKGQKLPV AEAIAYLLEI LPALSYLHSI GLVYNDLKPE NIMLTEEQLK LIDLGAVSRI 300
NSFGYLYGTP GFQAPEIVRT GPTVATDIYT VGRTLAALTL DLPTRNGRYV DGLPEDDPVL 360
KTYDSYGRLL RRAIDPDPRQ RFTTAEEMSA QLTGVLREVV AQDTGVPRPG LSTIFSPSRS 420
TFGVDLLVAH TDVYLDGQVH AEKLTANEIV TALSVPLVDP TDVAASVLQA TVLSQPVQTL 480
DSLRAARHGA LDADGVDFSE SVELPLMEVR ALLDLGDVAK ATRKLDDLAE RVGWRWRLVW 540
YRAVAELLTG DYDSATKHFT EVLDTFPGEL APKLALAATA ELAGNTDEHK FYQTVWSTND 600
GVISAAFGLA RARSAEGDRV GAVRTLDEVP PTSRHFTTAR LTSAVTLLSG RSTSEVTEEQ 660
IRDAARRVEA LPPTEPRVLQ IRALVLGGAL DWLKDNKAST NHILGFPFTS HGLRLGVEAS 720
LRSLARVAPT QRHRYTLVDM ANKVRPTSTF 750 |
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