UniProt Accession

 SIGH_MYCTO;  P9WGH8;  L0TEP5;  O05843;  P66807

Genbank Protein ID

 AE000516

Genbank Nucleotide ID

 AAK47662.1

Protein Name

 ECF RNA polymerase sigma factor SigH

Protein Synonyms/Alias

 ECF sigma factor SigH;  Sigma-H factor

Gene Name

 sigH

Gene Synonyms/Alias

 rpoE; OrderedLocusNames=MT3320

Created Date

 3-June-2014

Organism

 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

NCBI Taxa ID

 83331

Phosphorylation

Reference

 [1]Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis.
 Park ST,Kang CM,Husson RN
 Proc. Natl. Acad. Sci. U.S.A. 2008, Sep, 2;105(35):13105-10. [PMID:18728196]

Functional Description From UniProt

 FUNCTION: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and indirect control of up to 25% of the bacterial genome. Modulates expression of host genes for intercrine beta (chemokine CC) and apoptosis, altering the host immune response

Sequence Annotation From UniProt

 

Key Word From UniProt

 Completeproteome; DNA-binding; Phosphoprotein; Sigmafactor; Stressresponse; Transcription; Transcriptionregulation

Protein Sequence

  IPR014284   RNA_pol_sigma-70_dom.
  IPR014293   RNA_pol_sigma70_actinobac.
  IPR000838   RNA_pol_sigma70_ECF_CS.
  IPR007627   RNA_pol_sigma70_r2.
  IPR013249   RNA_pol_sigma70_r4_t2.
  IPR013325   RNA_pol_sigma_r2.
  IPR013324   RNA_pol_sigma_r3_r4.
  IPR011991   WHTH_DNA-bd_dom.

  PF04542   Sigma70_r2.
  PF08281   Sigma70_r4_2.

  PS01063   SIGMA70_ECF.