※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thiamine-phosphate synthase
Protein Synonyms/Alias
 TP synthase;  TPS;  TMP pyrophosphorylase;  TMP-PPase
Gene Name
 thiE
Gene Synonyms/Alias
 MT0427
Created Date
 3-June-2014
Organism
 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
NCBI Taxa ID
 83331
Phosphorylation
Position
Peptide
Code
Type
References
8 MHESRLASARLYLCT S HTP [1]
4 ****MHESRLASARL S HTP [1]
Reference
 [1]Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases.
 Prisic S,Dankwa S,Schwartz D,Chou MF,Locasale JW,Kang CM,Bemis G,Church GM,Steen H,Husson RN
 Proc. Natl. Acad. Sci. U.S.A. 2010, Apr, 20;107(16):7521-6. [PMID:20368441]
Functional Description From UniProt
 FUNCTION: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Completeproteome; Magnesium; Metal-binding; Thiaminebiosynthesis; Transferase
Protein Sequence
 MHESRLASAR LYLCTDARRE RGDLAQFAEA ALAGGVDIIQ LRDKGSPGEL RFGPLQARDE 60
 LAACEILADA AHRYGALFAV NDRADIARAA GADVLHLGQR DLPVNVARQI LAPDTLIGRS 120
 THDPDQVAAA AAGDADYFCV GPCWPTPTKP GRAAPGLGLV RVAAELGGDD KPWFAIGGIN 180
 AQRLPAVLDA GARRIVVVRA ITSADDPRAA AEQLRSALTA AN 222
  IPR013785   Aldolase_TIM.
  IPR022998   ThiaminP_synth_SF.
  IPR003733   TMP_synthase.
  PF02581   TMP-TENI.