※ Protein Information
Tag Content
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alanine--tRNA ligase
Protein Synonyms/Alias
 AlaRS
Gene Name
 alaS
Gene Synonyms/Alias
 SSO0341
Created Date
 3-June-2014
Organism
 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
NCBI Taxa ID
 273057
Phosphorylation
Position
Peptide
Code
Type
References
28 KICKSCQTPFWTKDD T HTP [1]
25 FKRKICKSCQTPFWT S HTP [1]
508 LQPTEKLYYKDQYMR Y HTP [1]
509 QPTEKLYYKDQYMRS Y HTP [1]
307 KIHRQMVSKELGIDI S HTP [1]
32 SCQTPFWTKDDKKEY T HTP [1]
513 KLYYKDQYMRSFEGK Y HTP [1]
Reference
 [1]Change of carbon source causes dramatic effects in the phospho-proteome of the archaeon Sulfolobus solfataricus.
 Esser D,Pham TK,Reimann J,Albers SV,Siebers B,Wright PC
 J. Proteome Res. 2012, Oct, 5;11(10):4823-33. [PMID:22639831]
Functional Description From UniProt
 FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Sequence Annotation From UniProt
 
Key Word From UniProt
 Aminoacyl-tRNAsynthetase; ATP-binding; Completeproteome; Cytoplasm; Ligase; Metal-binding; Nucleotide-binding; Proteinbiosynthesis; Referenceproteome; RNA-binding; tRNA-binding; Zinc
Protein Sequence
 MKASEEEYKL NFFIKNDFKR KICKSCQTPF WTKDDKKEYC SDIPCTDYYF FDINIKSQPL 60
 TVKEAREKFL SFFEKRGHTR IPPKPVLARW REDLYLTIAS IVDFQPHVTS GLVPPPANPL 120
 VVSQPSIRLE DIDNVGVTFG RHLTTFEMAA HHAFNYPDRY VYWKDETTAY ATEFFTKELG 180
 IPEEELNFKE SWWEGGGNAG PCLEVTVGGL ELATLVFMQY KITDNGDYIP LKLKIVDTGY 240
 GVERIAWVTQ KTPSAFHAIY GNLVYKFFDK IGVAYIDETL LKVASRFAGK IDPDNPDTIK 300
 IHRQMVSKEL GIDIKNVEEE LDRAAKVFQI LDHTKTIMLM LADGLVPSNS GEGYLGRLVI 360
 RRALKVLRLL KSDVRLYELV KEQIGFWKED FPQVLKNKDY ILDAVELEQQ RFEKILEKVP 420
 SIASTLARKS EITTEDLIQV YDSNGVPPDL LEEELKKKRV KFELPRNFYA LVAKRHQTST 480
 IKNVYDKVKL PKDLLEYITT LQPTEKLYYK DQYMRSFEGK VLGIYKNYLI LDKTTFYPEG 540
 GGQLGDTGLI IDEKSSKRYE VVDTQKVNDV IIHVLKEEPS TIKVGDNVRG EINWERRYRL 600
 MRHHTVTHVI LAAAKKVLGD HIWQAGAEKT PEKGRLDITH HKALTEEEVK LIENYANSVI 660
 SDRRPVKPLE MNRMEAEMKY GVSIYEGGVP NSATIRLLEI KDWDIESCGG THVSNTSEIG 720
 AVKIINVERI QDGIIRLEYV AGPALVDYIR ETEAKIAEAS KIIGTSPDQL PSRLRRILNE 780
 VEKKNNLIIQ YRRIVETELL NSLKPYEING NKIYIIEGLN DEEENKEILR KLTSTDNTIA 840
 ISISDNRLQI ATSKNMRVDK IVEELLKGGG KGGGKGTFAN VILSSKKSKE EIIDIVRKSL 900
  GO:0005737   C:cytoplasm IEA:UniProtKB-SubCell
  GO:0004813   F:alanine-tRNA ligase activity IEA:UniProtKB-HAMAP
  GO:0005524   F:ATP binding IEA:UniProtKB-HAMAP
  GO:0046872   F:metal ion binding IEA:UniProtKB-KW
  GO:0000049   F:tRNA binding IEA:UniProtKB-KW
  GO:0006419   P:alanyl-tRNA aminoacylation IEA:UniProtKB-HAMAP
  IPR002318   Ala-tRNA-lgiase_IIc.
  IPR018162   Ala-tRNA-ligase_IIc_anticod-bd.
  IPR018165   Ala-tRNA-synth_IIc_core.
  IPR018164   Ala-tRNA-synth_IIc_N.
  IPR022429   Ala-tRNA_lgiase_arc.
  IPR018163   Thr/Ala-tRNA-synth_IIc_edit.
  IPR009000   Transl_B-barrel.
  IPR012947   tRNA_SAD.
  PF01411   tRNA-synt_2c.
  PF07973   tRNA_SAD.
  SM00863   tRNA_SAD.
  PS50860   AA_TRNA_LIGASE_II_ALA.
  PR00980   TRNASYNTHALA.